与cordifolia Tinospora共同给药可减轻药物引起的肾毒性-组织学和生化评估

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL BioMedicine-Taiwan Pub Date : 2023-07-01 DOI:10.51248/.v43i3.1698
Janani Maheshwari V. Vyas, S. Kumar S., Leena Dennis Joseph, K. P, S. R
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引用次数: 0

摘要

前言与目的:在早期文献中,各种草药被用来治疗肾脏疾病。肾保护草药对肾毒性有保护作用。Tinospora cordifolia以其治疗糖尿病和肾脏及代谢紊乱的作用而闻名。然而,对其在不同时期对药物肾毒性的保护作用的研究还很缺乏。目的是研究堇青花对药物引起的肾毒性变化的保护作用,该草药与药物引起的肾毒性共同给药。材料与方法:制备了堇青花茎的乙醇提取物,并对其化学成分进行了评价。采用庆大霉素致成年雄性Wistar大鼠肾毒性模型进行研究。庆大霉素与堇青花提取物联合用药8 d。在肾脏中,测量超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、还原性谷胱甘肽和脂质过氧化水平。采用组织病理学严重程度分级对肾组织进行评估。结果:堇青花茎中含有苷类、黄酮类、皂苷类、甾体、醌类和香豆素等植物化学成分。分析肾脏中的氧化应激和抗氧化剂水平揭示了还原型谷胱甘肽(GSH)水平的上升。这与中药提取物对庆大霉素肾毒性引起的肾组织急性小管坏死所带来的再生变化有关,在组织学水平上表现为小管上皮扩大和再生的减少。结论:青藤提取物中含有黄酮类化合物,是已知的抗氧化剂。在药物引起的肾毒性情况下,同时服用堇青花茎提取物具有保护作用,因此,在服用潜在肾毒性药物的同时服用,对肾脏有益。
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Co-administration with Tinospora cordifolia attenuates drug induced nephrotoxicity – A histological and biochemical assessment
Introduction and Aim: Various herbs have been prescribed as a cure for renal disorders by early literature. Nephroprotective herbs are protective against nephrotoxicity. Tinospora cordifolia is known for its role in treating diabetes and disorders of the kidney and metabolism. However, studying its protective effect on drug induced nephrotoxicity at different time periods is wanting. The aim is to study the nephroprotective effect of Tinospora cordifolia on drug induced nephrotoxic changes upon co-administration of the herb with nephrotoxicity induction by the drug.   Materials and Methods: Ethanolic extract of the stem of Tinospora cordifolia was prepared and evaluated for phytochemical constituents. Gentamicin induced nephrotoxicity model in adult, male, Wistar rats was utilised for the study. Gentamicin and the extract of Tinospora cordifolia were co-administered for 8 days. In the kidney, levels of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxidation were measured. Assessment of the renal tissue was carried out using histopathological severity grading.   Results: Phytochemicals like glycosides, flavonoids, saponins, steroids, quinone and coumarin were present in the stem of Tinospora cordifolia. Analysing the levels of oxidative stress and antioxidants in the kidney revealed the rise in the level of reduced glutathione (GSH). This correlated with the regenerative changes brought about by the herbal extract on the acute tubular necrosis in the renal tissue induced due to gentamicin nephrotoxicity, at the histological levels in terms of the reduction of enlargement and regeneration of the tubular epithelium.   Conclusion: Tinospora cordifolia extract constituted flavonoids which are known antioxidants. Co-administration of Tinospora cordifolia stem extract is protective in the nephrotoxic condition induced by drugs, hence, shall benefit the kidney when taken along while consuming potentially nephrotoxic drugs.
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来源期刊
BioMedicine-Taiwan
BioMedicine-Taiwan MEDICINE, GENERAL & INTERNAL-
CiteScore
2.80
自引率
5.90%
发文量
21
审稿时长
24 weeks
期刊最新文献
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