脂质代谢异常是侵袭性结直肠癌的一个可操作的弱点

IF 2.6 Q3 ONCOLOGY Molecular and Cellular Oncology Pub Date : 2022-01-27 DOI:10.1080/23723556.2021.2024051

D. Capece, G. Franzoso

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引用次数: 3

摘要

摘要癌症细胞重新编程脂质代谢以促进细胞分裂、适应压力和转移扩散。NF-κB转录因子通过三酰甘油（TAG）脂肪酶、羧酸酯酶1（CES1）在结直肠癌（CRC）侵袭性共有分子亚型（CMS）4中控制这一机制，从而将肥胖相关炎症与代谢适应和细胞保护作用联系起来，使其免受脂质诱导的毒性。我们的发现确定了一种治疗易转移CRC患者的潜在治疗途径，并为靶向CRC以外癌症中基于核心肿瘤亚型的脆弱性提供了一个例子。

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Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma

ABSTRACT Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this mechanism in aggressive Consensus Molecular Subtype (CMS)4 of colorectal carcinoma (CRC) via triacylglycerol (TAG) lipase, carboxylesterase 1 (CES1), thereby linking obesity-associated inflammation with metabolic adaptation and cytoprotection from lipid-induced toxicity. Our findings identify a potential therapeutic route to treat patients with metastasis-prone CRC and provide an example for targeting core tumor subtype-based vulnerabilities in cancers beyond CRC.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.