抗肺炎药用植物复方研究进展

Megha Patel, Bhavesh Sharma
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引用次数: 0

摘要

细菌、流感、寄生虫和真菌是引起传染病的病原微生物。疾病可以直接或间接地从一个人传染给另一个人。传染病是世界上第二大常见死因。雨林植物提供了我们所需药物的四分之一。对一些药用植物进行了科学研究,但研究程度很低。细菌对目前有效的抗生素的敏感性使得发现新的抗菌剂成为必要。在印度的农村和落后地区,有几种植物被广泛用作治疗传染病的草药。这一章回顾了用于治疗疟疾、肺炎等疾病的药用植物的出版物。由于各种原因,包括其可负担性和有效性,传统医学在许多农村地区是首选的初级卫生保健系统。目前的研究主要集中在现有的药用植物文献上,突出了民族植物学、植物化学和药理学的细节。所有被检测的植物都显示出有效的作用,支持它们的传统用途以及治疗常见疾病的能力。姜黄(Curcuma longa L.)、石榴树(Punica granatum L.)和苦参(Justicia adhatoda L.)是研究区应用最广泛的治疗肺炎植物科(各7株);其中对金黄色葡萄球菌和肺炎链球菌的抑制能力最强的是姜黄、石榴和白芷。抗坏血酸、姜黄素、缬草碱、胡椒碱、槲皮素、杨梅素和没食子酸都是从这些植物中提取的,据说它们具有抗菌特性。虽然喜马拉雅地区有广泛的民族药用植物用于治疗肺炎,但对其体内活性、毒理学和作用机制的研究很少。因此,为了从已研究的植物物种中生产出新的抗菌药物,需要对这些方面进行深入的研究。
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Recent Advances of the Medicinal Plant Compound for Combating Pneumonia Disease: A Review
Bacteria, influenza, parasites and fungi are pathogenic microorganisms that cause infectious diseases. Diseases can spread from one individual to another, either directly or indirectly. Infectious diseases are world’s second most common cause of death. Rainforest plants provide about quarter of drugs we need. Scientific research has been carried out on few medicinal plants, but only to small degree. Bacterial susceptibility to currently active antibiotics has necessitated discovery of new antibacterial agents. Several plants are widely used as herbal medicine for treatment of infectious diseases in rural and backward areas of India. This chapter looks over the publications on medicinal plants that are used to cure diseases like malaria, pneumonia. Traditional medicine is preferred primary health care system in many rural areas for variety of reasons, including its affordability and efficacy. The current study focused on existing medicinal plant literature, with ethnobotany, phytochemistry and pharmacology details being highlighted. All of examined plants showed potent action, supporting their conventional uses as well as their ability to cure common diseases. Curcuma longa L., Punica granatum L. and Justicia adhatoda L. were most widely used plant families for pneumonia therapy in research area (each with seven plants); of these, Curcuma longa L., Punica granatum L. and Justicia adhatoda L. had most inhibiting ability against Staphylococcus aureus and Streptococcus pneumoniae. Ascorbic acid, curcumin, vasicine, piperine, quercetin, myricetin and gallic acid have all been derived from these plants and are said to have antibacterial properties. Although Himalayan region has wide range of ethnomedicinal plants used to treat pneumonia, research on in-vivo activity, toxicology, and mechanism of action is minimal. As result, in order to produce novel antibacterial drugs from studied plant species, thorough study of these aspects is needed.
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