Li-Qin Yang, K. Zhang, Qiuying Wu, J. Li, Song-Jia Lai, T. Song, Ming Zhang
{"title":"肌肉抑制素（MSTN）基因两个新的单核苷酸多态性位点的鉴定及其与肉兔胴体性状的关系","authors":"Li-Qin Yang, K. Zhang, Qiuying Wu, J. Li, Song-Jia Lai, T. Song, Ming Zhang","doi":"10.4995/wrs.2019.10610","DOIUrl":null,"url":null,"abstract":"<p>Two unknown single nucleotide polymorphism (SNP) sites in exons 1 (c.194C>T) and 2 (c.445T>A) of meat-type rabbit <em>MSTN</em> gene were identified in the study. Our objective was to analyse the population genetics structure of the two novel SNP sites in 230 individuals from six breeds and their associations with carcass traits of rabbits. We found that live body weight (BW), cold carcass weight (CCW), reference carcass weight (RCW), CCW percentage (P<sub>CCW</sub>) and RCW percentage (P<sub>RCW</sub>) of the rabbits with the genotype CC at the c.194C>T of exon 1 or AA at the c.445T>A of exon 2 were significantly higher than those with other genotypes. Diplotype significantly affected BW, RCW, CCW, P<sub>RCW</sub> (<em>P</em><0.01) and P<sub>CCW</sub> and P<sub>CM</sub> (<em>P</em><0.05). CC/AA was the advantageous diplotype for BW, RCW, CCW and P<sub>CM</sub>, and TT/AA was the advantageous diplotype for P<sub>CCW</sub> and P<sub>RCW</sub>. In contrast, TT/TT was the negative diplotype for BW, CCW, RCW, P<sub>CCW</sub> and P<sub>RCW</sub>, and TT/AA was the negative diplotype for P<sub>CM</sub>. The results suggest that the two new mutations of <em>MSTN</em> gene significantly affected BW, CCW, RCW, P<sub>CCW</sub> and P<sub>RCW</sub> of rabbits, and <em>MSTN</em> may be an important candidate gene of carcass traits in meat-type rabbits.</p>","PeriodicalId":23902,"journal":{"name":"World Rabbit Science","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2019-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Identification of two novel single nucleotide polymorphism sites in the Myostatin (MSTN) gene and their association with carcass traits in meat-type rabbits (Oryctolagus cuniculus)\",\"authors\":\"Li-Qin Yang, K. Zhang, Qiuying Wu, J. Li, Song-Jia Lai, T. Song, Ming Zhang\",\"doi\":\"10.4995/wrs.2019.10610\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Two unknown single nucleotide polymorphism (SNP) sites in exons 1 (c.194C>T) and 2 (c.445T>A) of meat-type rabbit <em>MSTN</em> gene were identified in the study. Our objective was to analyse the population genetics structure of the two novel SNP sites in 230 individuals from six breeds and their associations with carcass traits of rabbits. We found that live body weight (BW), cold carcass weight (CCW), reference carcass weight (RCW), CCW percentage (P<sub>CCW</sub>) and RCW percentage (P<sub>RCW</sub>) of the rabbits with the genotype CC at the c.194C>T of exon 1 or AA at the c.445T>A of exon 2 were significantly higher than those with other genotypes. Diplotype significantly affected BW, RCW, CCW, P<sub>RCW</sub> (<em>P</em><0.01) and P<sub>CCW</sub> and P<sub>CM</sub> (<em>P</em><0.05). CC/AA was the advantageous diplotype for BW, RCW, CCW and P<sub>CM</sub>, and TT/AA was the advantageous diplotype for P<sub>CCW</sub> and P<sub>RCW</sub>. In contrast, TT/TT was the negative diplotype for BW, CCW, RCW, P<sub>CCW</sub> and P<sub>RCW</sub>, and TT/AA was the negative diplotype for P<sub>CM</sub>. The results suggest that the two new mutations of <em>MSTN</em> gene significantly affected BW, CCW, RCW, P<sub>CCW</sub> and P<sub>RCW</sub> of rabbits, and <em>MSTN</em> may be an important candidate gene of carcass traits in meat-type rabbits.</p>\",\"PeriodicalId\":23902,\"journal\":{\"name\":\"World Rabbit Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2019-12-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Rabbit Science\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.4995/wrs.2019.10610\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Rabbit Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.4995/wrs.2019.10610","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
Identification of two novel single nucleotide polymorphism sites in the Myostatin (MSTN) gene and their association with carcass traits in meat-type rabbits (Oryctolagus cuniculus)
Two unknown single nucleotide polymorphism (SNP) sites in exons 1 (c.194C>T) and 2 (c.445T>A) of meat-type rabbit MSTN gene were identified in the study. Our objective was to analyse the population genetics structure of the two novel SNP sites in 230 individuals from six breeds and their associations with carcass traits of rabbits. We found that live body weight (BW), cold carcass weight (CCW), reference carcass weight (RCW), CCW percentage (PCCW) and RCW percentage (PRCW) of the rabbits with the genotype CC at the c.194C>T of exon 1 or AA at the c.445T>A of exon 2 were significantly higher than those with other genotypes. Diplotype significantly affected BW, RCW, CCW, PRCW (P<0.01) and PCCW and PCM (P<0.05). CC/AA was the advantageous diplotype for BW, RCW, CCW and PCM, and TT/AA was the advantageous diplotype for PCCW and PRCW. In contrast, TT/TT was the negative diplotype for BW, CCW, RCW, PCCW and PRCW, and TT/AA was the negative diplotype for PCM. The results suggest that the two new mutations of MSTN gene significantly affected BW, CCW, RCW, PCCW and PRCW of rabbits, and MSTN may be an important candidate gene of carcass traits in meat-type rabbits.
期刊介绍：
World Rabbit Science is the official journal of the World Rabbit Science Association (WRSA). One of the main objectives of the WRSA is to encourage communication and collaboration among individuals and organisations associated with rabbit production and rabbit science in general. Subject areas include breeding, genetics, production, management, environment, health, nutrition, physiology, reproduction, behaviour, welfare, immunology, molecular biology, metabolism, processing and products.
World Rabbit Science is the only international peer-reviewed journal included in the ISI Thomson list dedicated to publish original research in the field of rabbit science. Papers or reviews of the literature submitted to World Rabbit Science must not have been published previously in an international refereed scientific journal. Previous presentations at a scientific meeting, field day reports or similar documents can be published in World Rabbit Science, but they will be also subjected to the peer-review process.
World Rabbit Science will publish papers of international relevance including original research articles, descriptions of novel techniques, contemporaryreviews and meta-analyses. Short communications will only accepted in special cases where, in the Editor''s judgement, the contents are exceptionally exciting, novel or timely. Proceedings of rabbit scientific meetings and conference reports will be considered for special issues.
World Rabbit Science is published in English four times a year in a single volume. Authors may publish in World Rabbit Science regardless of the membership in the World Rabbit Science Association, even if joining the WRSA is encouraged. Views expressed in papers published in World Rabbit Science represent the opinion of the author(s) and do not necessarily reflect the official policy of the WRSA or the Editor-in-Chief.
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