hbv相关、hcv相关和非hbv非hcv肝细胞癌术后预后的比较:一项系统综述和荟萃分析

IF 0.3 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Hepatitis Monthly Pub Date : 2022-08-01 DOI:10.5812/hepatmon-121820
Yue Zhao, Yuanyuan Jia, Sufen Qi, Chensi Wu, Jianhua Wu, Ruixing Zhang, Jing Li, Zhanjun Guo
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引用次数: 0

摘要

背景:肝细胞癌(HCC)是癌症最常见的原发性肝癌,不同的肝炎病毒可能影响HCC患者的预后。目的:本研究旨在揭示乙型肝炎病毒相关性肝癌(HBV-HCC)、丙型肝炎病毒相关性HCC(HCV-HCC和非HBV非HCV肝细胞癌(NBNC-HCC)患者术后预后的差异。方法:检索PubMed、Embase、Cochrane、Web of Science和Scopus数据库中截至2022年4月发表的文章。Stata软件版本12和Review Manager版本5.4用于进行荟萃分析,本研究采用了系统评价和荟萃分析的首选报告项目(PRISMA)声明。结果:在本研究中,分析了26篇论文,共20381名符合纳入标准的参与者。HBV-HCC和HCV-HCC组的5年总生存率低于NBNC-HCC组(HBV-HCCvs.NBNC-HCC,P=0.005;HCV-HCCvs.NB NC-HCC,P=0.001)。此外,HCC组的5年无复发率低于HBV-HCC组(P=0.0)。观察到的血清甲胎蛋白水平与术后预后之间的相关性在不同的亚组中是不一致的。结论:NBNC-HCC患者的术后预后明显好于病毒相关HCC患者。甲胎蛋白水平与HCC患者术后预后显著相关。
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Comparison of Postoperative Prognosis Among HBV-Related, HCV-Related, and non-HBV non-HCV Hepatocellular Carcinomas: A Systematic Review and Meta-analysis
Context: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, and different hepatitis viruses might affect the prognosis of patients with HCC. Objectives: This study aimed to reveal the differences in the postoperative prognosis of patients with hepatitis B virus-related HCC (HBV-HCC), hepatitis C virus-related HCC (HCV-HCC), and non-HBV non-HCV hepatocellular carcinoma (NBNC-HCC). Methods: The databases PubMed, Embase, Cochrane, Web of Science, and Scopus were searched for articles published until April 2022. Stata software version 12 and Review Manager version 5.4 were used to conduct the meta-analysis, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was adopted in this study. Results: In the present study, 26 papers on a total of 20381 participants who met the inclusion criteria were analyzed. The 5-year overall survival in the HBV-HCC and HCV-HCC groups was lower than in the NBNC-HCC group (HBV-HCC vs. NBNC-HCC, P = 0.005; HCV-HCC vs. NBNC-HCC, P = 0.001). Patients with HBV-HCC and HCV-HCC had worse 5-year recurrence-free survival than patients with NBNC-HCC (HBV-HCC vs. NBNC-HCC, P = 0; HCV-HCC vs. NBNC-HCC, P = 0). In addition, the 5-year recurrence-free rate in the HCV-HCC group was lower than in the HBV-HCC group (P = 0). The observed association between serum alpha-fetoprotein levels and the postoperative prognosis was inconsistent in different subgroups. Conclusions: Patients with NBNC-HCC had a significantly better postoperative prognosis than those with virus-related HCC. The alpha-fetoprotein levels significantly correlated with the postoperative prognosis of patients with HCC.
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来源期刊
Hepatitis Monthly
Hepatitis Monthly 医学-胃肠肝病学
CiteScore
1.50
自引率
0.00%
发文量
31
审稿时长
3 months
期刊介绍: Hepatitis Monthly is a clinical journal which is informative to all practitioners like gastroenterologists, hepatologists and infectious disease specialists and internists. This authoritative clinical journal was founded by Professor Seyed-Moayed Alavian in 2002. The Journal context is devoted to the particular compilation of the latest worldwide and interdisciplinary approach and findings including original manuscripts, meta-analyses and reviews, health economic papers, debates and consensus statements of the clinical relevance of hepatological field especially liver diseases. In addition, consensus evidential reports not only highlight the new observations, original research, and results accompanied by innovative treatments and all the other relevant topics but also include highlighting disease mechanisms or important clinical observations and letters on articles published in the journal.
期刊最新文献
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