测定亲水/亲脂性物质抗氧化活性的体外选择方法

IF 0.9 Q4 CHEMISTRY, MULTIDISCIPLINARY Acta Chimica Slovaca Pub Date : 2019-10-01 DOI:10.2478/acs-2019-0028
A. Ácsová, Silvia Martiniaková, J. Hojerová
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引用次数: 10

摘要

摘要自由基及其相关抗氧化剂是近年来研究的热点。抗氧化剂有助于在破坏细胞之前中和自由基。在缺乏抗氧化剂的情况下,就会出现一种叫做氧化应激的现象。氧化应激可引起许多疾病,如阿尔茨海默病和心血管疾病。因此,必须对各种化合物的抗氧化活性及其作用机制进行研究。通过体外和体内方法测定抗氧化活性和抗氧化能力;根据自由基和抗氧化剂之间的化学反应,体外方法分为两组。第一组是基于氢原子的转移(HAT),第二组是基于电子的转移(ET)。本文讨论了抗氧化能力测定中常用的几种方法的原理、机理、方法、结果评价方法和可能存在的缺陷。
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Selectedin vitro methods to determine antioxidant activity of hydrophilic/lipophilic substances
Abstract The topic of free radicals and related antioxidants is greatly discussed nowadays. Antioxidants help to neutralize free radicals before damaging cells. In the absence of antioxidants, a phenomenon called oxidative stress occurs. Oxidative stress can cause many diseases e.g. Alzheimer’s disease and cardiovascular diseases. Therefore, antioxidant activity of various compounds and the mechanism of their action have to be studied. Antioxidant activity and capacity are measured by in vitro and in vivo methods; in vitro methods are divided into two groups according to chemical reactions between free radicals and antioxidants. The first group is based on the transfer of hydrogen atoms (HAT), the second one on the transfer of electrons (ET). The most frequently used methods in the field of antioxidant power measurement are discussed in this work in terms of their principle, mechanism, methodology, the way of results evaluation and possible pitfalls.
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Acta Chimica Slovaca
Acta Chimica Slovaca CHEMISTRY, MULTIDISCIPLINARY-
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12.50%
发文量
11
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