Rachel R. Rix , Raul Narciso C. Guedes , G. Christopher Cutler
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Hormesis dose–response contaminant-induced hormesis in animals
Hormesis is a toxicological phenomenon whereby exposures to low doses of stress result in biological stimulation. The hormetic dose response is now recognized as a dominant response in toxicology occurring in a wide variety of organisms following exposure to numerous forms of stress. Here we briefly review recent research showing occurrences of hormesis in animals following exposure to frequently occurring and environmentally relevant contaminants/pollutants, including metals, industrial chemicals, pesticides, pharmaceuticals, and plastics. We also show evidence for underlying mechanisms for hormesis. We conclude by highlighting the importance of considering low-dose effects and hormesis when studying the consequences of environmental contamination/pollution.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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