先天性胃肠畸形的临床特征和预后:一项单一医院的研究

IF 0.3 Q4 PEDIATRICS Journal of Pediatrics Review Pub Date : 2022-03-06 DOI:10.32598/jpr.10.1.989.1
K. Kumar, P. Thakur, Shilpi Singh
{"title":"先天性胃肠畸形的临床特征和预后:一项单一医院的研究","authors":"K. Kumar, P. Thakur, Shilpi Singh","doi":"10.32598/jpr.10.1.989.1","DOIUrl":null,"url":null,"abstract":"Aims: To determine the prevalence, clinical profile and outcomes of gastrointestinal (GI) malformations in neonates in a tertiary care hospital. Settings and Design: A prospective observational case-control study was conducted at a tertiary care hospital in New Delhi. Methods: The study was conducted on live neonates from October 2014 to November 2015. Cases of neonates with GI malformations were compared against healthy babies. Outcome measures assessed were prevalence, associated risk factors, clinical profile, and mortality of GI malformation. Statistical analysis: Qualitative variables were compared using Chi-Square test/Fisher’s exact test. Multivariate logistic regression was used to assess the significant risk factors after adjusting for confounding variables. A P-value <0.05 was considered statistically significant. Results: Among the 25,116 live births, 41 cases were diagnosed with GI malformations. To compare, 82 controls (healthy babies) were taken. The prevalence of GI malformations was 0.163 or 1.63/1,000 live births with a male to female ratio of 1.1:1. The tracheoesophageal fistula was the most frequent anomaly (39.02%). Multivariate analysis revealed a lack of periconceptional iron and folic acid supplementation and baby birth weight <2.5 kg as independent significant factors related to the occurrence of congenital GI defects (when compared to controls). Among 41 cases, 20 neonates died (48.78% mortality rate). Causes of mortality were prematurity, sepsis, asphyxia, and shock. Conclusion: In a developing country like ours, the association of GI malformations (0.163%) with lack of periconceptional iron and folic acid supplementation and low birth weight shows that increased counseling and implementation of the supplements during the pregnancy can help decrease the prevalence. Mortality remains high among such children and thus they demand urgent necessary surgery and management.","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.3000,"publicationDate":"2022-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Profile and Outcomes of Congenital Gastrointestinal Malformations: A Single Hospital Study\",\"authors\":\"K. Kumar, P. Thakur, Shilpi Singh\",\"doi\":\"10.32598/jpr.10.1.989.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aims: To determine the prevalence, clinical profile and outcomes of gastrointestinal (GI) malformations in neonates in a tertiary care hospital. Settings and Design: A prospective observational case-control study was conducted at a tertiary care hospital in New Delhi. Methods: The study was conducted on live neonates from October 2014 to November 2015. Cases of neonates with GI malformations were compared against healthy babies. Outcome measures assessed were prevalence, associated risk factors, clinical profile, and mortality of GI malformation. Statistical analysis: Qualitative variables were compared using Chi-Square test/Fisher’s exact test. Multivariate logistic regression was used to assess the significant risk factors after adjusting for confounding variables. A P-value <0.05 was considered statistically significant. Results: Among the 25,116 live births, 41 cases were diagnosed with GI malformations. To compare, 82 controls (healthy babies) were taken. The prevalence of GI malformations was 0.163 or 1.63/1,000 live births with a male to female ratio of 1.1:1. The tracheoesophageal fistula was the most frequent anomaly (39.02%). Multivariate analysis revealed a lack of periconceptional iron and folic acid supplementation and baby birth weight <2.5 kg as independent significant factors related to the occurrence of congenital GI defects (when compared to controls). Among 41 cases, 20 neonates died (48.78% mortality rate). Causes of mortality were prematurity, sepsis, asphyxia, and shock. Conclusion: In a developing country like ours, the association of GI malformations (0.163%) with lack of periconceptional iron and folic acid supplementation and low birth weight shows that increased counseling and implementation of the supplements during the pregnancy can help decrease the prevalence. Mortality remains high among such children and thus they demand urgent necessary surgery and management.\",\"PeriodicalId\":43059,\"journal\":{\"name\":\"Journal of Pediatrics Review\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2022-03-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pediatrics Review\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32598/jpr.10.1.989.1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pediatrics Review","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32598/jpr.10.1.989.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0

摘要

目的:确定三级护理医院新生儿胃肠道畸形的患病率、临床特征和结果。设置和设计:在新德里的一家三级护理医院进行了一项前瞻性观察性病例对照研究。方法:本研究于2014年10月至2015年11月对活体新生儿进行。将患有胃肠道畸形的新生儿病例与健康婴儿进行比较。评估的结果指标包括胃肠道畸形的患病率、相关危险因素、临床特征和死亡率。统计分析:使用卡方检验/Fisher精确检验对定性变量进行比较。在校正混杂变量后,使用多变量逻辑回归来评估显著的风险因素。P值<0.05被认为具有统计学意义。结果:25116例活产婴儿中,41例被诊断为胃肠道畸形。为了进行比较,选取了82名对照(健康婴儿)。胃肠道畸形的发生率为0.163或1.63/1000活产,男女比例为1.1:1。气管食管瘘是最常见的异常(39.02%)。多因素分析显示,围产期缺乏铁和叶酸补充以及婴儿出生体重<2.5kg是与先天性胃肠道缺陷发生相关的独立显著因素(与对照组相比)。41例新生儿死亡20例,死亡率48.78%。死亡原因为早产、败血症、窒息和休克。结论:在我们这样的发展中国家,胃肠道畸形(0.163%)与围产期缺乏铁和叶酸补充剂以及低出生体重有关,这表明在怀孕期间加强咨询和实施补充剂有助于降低患病率。这些儿童的死亡率仍然很高,因此他们迫切需要进行必要的手术和管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Clinical Profile and Outcomes of Congenital Gastrointestinal Malformations: A Single Hospital Study
Aims: To determine the prevalence, clinical profile and outcomes of gastrointestinal (GI) malformations in neonates in a tertiary care hospital. Settings and Design: A prospective observational case-control study was conducted at a tertiary care hospital in New Delhi. Methods: The study was conducted on live neonates from October 2014 to November 2015. Cases of neonates with GI malformations were compared against healthy babies. Outcome measures assessed were prevalence, associated risk factors, clinical profile, and mortality of GI malformation. Statistical analysis: Qualitative variables were compared using Chi-Square test/Fisher’s exact test. Multivariate logistic regression was used to assess the significant risk factors after adjusting for confounding variables. A P-value <0.05 was considered statistically significant. Results: Among the 25,116 live births, 41 cases were diagnosed with GI malformations. To compare, 82 controls (healthy babies) were taken. The prevalence of GI malformations was 0.163 or 1.63/1,000 live births with a male to female ratio of 1.1:1. The tracheoesophageal fistula was the most frequent anomaly (39.02%). Multivariate analysis revealed a lack of periconceptional iron and folic acid supplementation and baby birth weight <2.5 kg as independent significant factors related to the occurrence of congenital GI defects (when compared to controls). Among 41 cases, 20 neonates died (48.78% mortality rate). Causes of mortality were prematurity, sepsis, asphyxia, and shock. Conclusion: In a developing country like ours, the association of GI malformations (0.163%) with lack of periconceptional iron and folic acid supplementation and low birth weight shows that increased counseling and implementation of the supplements during the pregnancy can help decrease the prevalence. Mortality remains high among such children and thus they demand urgent necessary surgery and management.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
20
审稿时长
8 weeks
期刊最新文献
The Effect of Sleep Disorders on Blood Sugar in Children With Type 1 Diabetes Mellitus The Effect of Chicory on Bilirubin Level in Newborns Suffering From Jaundice: A Systematic Review Case Series of Prolonged Febrile Illness in Pediatric Age Group: A Diagnostic Challenge Aplasia Cutis Congenita in a Newborn of Diabetic Mother: A Case Report and Review of Literature Solid Pseudopapillary Tumor of Pancreas in a 14-year-old Adolescent Presenting With Melena: A Case Report
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1