转录因子7-like 2 rs4506565 (T/A)变异与伊拉克阿拉伯患者2型糖尿病的关系

IF 0.8 Q4 GENETICS & HEREDITY Meta Gene Pub Date : 2022-02-01 DOI:10.1016/j.mgene.2021.101008

Abdullah Sami Abdullah, Seenaa Kadhum Ali

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引用次数: 1

摘要

研究人员一直将一些TCF7L2基因变异(如rs7903146、rs12255372和rs11255372)与许多人群和种族群体中的2型糖尿病(T2DM)联系起来。本研究的目的是显示TCF7L2变异rs4506565 T/A是否与伊拉克阿拉伯患者的2型糖尿病有关。为此，我们对100名T2DM患者和100名对照者进行了病例对照研究。利用新设计的引物，采用四引物ARMS-PCR技术对TCF7L2 rs4506565 T/A进行基因分型。本研究得出TCF7L2基因多态性rs4506565 T/A在共显性、显性、过显性、隐性和加性模型中的基因型均无显著差异。优势模型对年龄有显著性，对其他参数无显著性。

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Assessment of the relationship of transcription factor 7-like 2 rs4506565 (T/A) variant with type 2 diabetes in Iraqi Arab patients

Researchers have consistently linked some TCF7L2 gene variations, such as rs7903146, rs12255372, and rs11255372, to Type 2 diabetes mellitus (T2DM) in numerous populations and ethnic groups. The goal of this study is to show if the TCF7L2 variations rs4506565 T/A is linked to T2DM in Iraqi Arab patients. For this purpose, a case-control study was conducted with 100 T2DM patients and 100 controls. The Tetra-Primer ARMS-PCR Technique was used to genotype TCF7L2 rs4506565 T/A, making use of newly-designed primers. The study concluded that the TCF7L2 gene polymorphism rs4506565 T/A shows no significant difference in genotypes in any of the codominant, dominant, over dominant, recessive, and additive models. The dominant model has a significance with age but no significance with other parameters.

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来源期刊

Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.