2-羟乙醛衍生试剂测定赖诺普利的纯度和片剂含量

IF 0.4 Q4 CHEMISTRY, ANALYTICAL Pakistan Journal of Analytical & Environmental Chemistry Pub Date : 2021-06-23 DOI:10.21743/pjaec/2021.06.12
Zahid Ali Zounr
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引用次数: 1

摘要

建立了一种简单、灵敏、准确的基于2-羟基萘乙醛(2HNA)衍生化反应的分光光度法测定莱诺普利(LNP)纯制剂和片剂含量的方法。在pH-5.5的甲醇溶剂中,在95±2的频率下进行衍生化反应,反应时间为15 min。得到LNP在433 nm的浓度范围5 ~ 50 μgmL-1内符合比尔定律的线性标定曲线,测定系数R²=0.996。加样回收率为98.25 ~ 101.82,药物的摩尔吸光度为9×103 mol -1cm-1。方法准确、精密度高(日内变化0.05 ~ 0.97%,日内变化0.07 ~ 1.6%),检测限(LOD)和定量限(LOQ)分别为0.264 μgmL-1和0.8 μgmL-1。未检测到辅料的干扰。该方法可用于药品中LNP的快速分析。
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Determination of Lisinopril in Pure and Tablet form by Using 2-Hydroxynaphthaldehyde as Derivatizing Reagent
An easy, sensitive and accurate spectrophotometric method has been developed for the determination of Lisinopril (LNP) in pure and tablet formulations based on derivatization reaction with 2-hydroxynaphthaldehyde (2HNA). The derivatization reaction was carried out in methanol solvent at pH-5.5 at 95±2C for 15 min. The linear calibration curve was obtained that obeyed the Beer’s law within the concentration range 5-50 μgmL-1 of LNP at 433 nm with a coefficient of determination R²=0.996. The recovery was in the range from 98.25-101.82 with molar absorptivity of drug 9×103 mole-1cm-1. The method was accurate and precise (intra-day variation 0.05-0.97% and inter-day 0.07-1.6%), with limit of detection (LOD) and limit of quantification (LOQ) 0.264 μgmL-1 and 0.8 μgmL-1, respectively. No interferences from the excipients were detected. The method was applied for the rapid analysis of LNP in pharmaceutical products.
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来源期刊
CiteScore
1.10
自引率
16.70%
发文量
16
审稿时长
15 weeks
期刊最新文献
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