莫纳可林K联合辅酶Q10、葡萄籽和橄榄叶提取物改善轻至中度高胆固醇血症患者血脂的有效性和安全性:一项自我控制研究

N. Angelopoulos, R. Paparodis, I. Androulakis, A. Boniakos, P. Anagnostis, V. Tsimihodimos, S. Livadas
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引用次数: 4

摘要

本研究的目的是评估一种含有monacolin K与辅酶Q10以及葡萄籽和橄榄叶提取物(Arichol®®)的新型膳食补充剂对中度胆固醇升高且无相关风险因素的成年人的脂质状况的降脂功效和安全性。我们从希腊内分泌诊所招募了低密度脂蛋白胆固醇(LDL-C)为140–180 mg/dL的患者,他们没有服用影响血脂浓度的药物,并同意参与本研究。所有受试者接受为期8周的Arichol®补充剂,每天一次。我们在基线和研究结束时用酶比色法测量了总胆固醇(TC)、高密度脂蛋白胆固醇(HDL)、LDL-C、甘油三酯(TG)和肝酶,并记录了可能归因于肌肉损伤的主诉。我们共招募了37名受试者,33名女性和4名男性(平均年龄为55.89±1.50[平均值±标准误差平均值,SEM])。治疗导致TC(从258.9±4.0 mg/dL降至212.7±4.5 mg/dL,p<0.001)、LDL-C(从173.8±3.5降至129.0±4.5 mg/d L,p>0.001)和TG(从127.0±12.2降至117.0±9.2,mg/dL)浓度在统计学上显著降低,而HDL-C浓度保持不变。任何受试者的肝酶或肌肉疼痛症状均无变化。这些有希望的结果表明,补充这种营养品混合物在短时间内对脂质浓度产生有利影响,同时表现出良好的安全性。需要进行更大规模的对照研究来评估上述化合物降低心血管风险的潜力。
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Efficacy and Safety of Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts in Improving Lipid Profile of Patients with Mild-to-Moderate Hypercholesterolemia: A Self-Control Study
The objective of the present study was to assess the lipid-lowering efficacy and safety of a novel dietary supplement containing monacolin K combined with the coenzyme Q10 and grape seed and olive tree leaf extracts (Arichol®®) on the lipid profile of adults with moderate cholesterol elevations and an absence of concomitant risk factors. We recruited patients from our Endocrinology Clinics in Greece who had low-density lipoprotein cholesterol (LDL-C) 140–180 mg/dL, were on no medications affecting serum lipid concentrations, and consented to participate in the present study. All subjects received 8-weeks supplementation with Arichol®® once daily. We measured total cholesterol (TC), high-density lipoprotein cholesterol (HDL), LDL-C, triglycerides (TG), and liver enzymes with enzymatic colorimetric assays at baseline and at the end of the study, and documented complaints potentially attributable to muscle injury. We recruited a total of 37 subjects, 33 females and 4 males (with a mean age of 55.89 ± 1.50 [mean ± standard error mean, SEM]). The treatment resulted in a statistically significant reduction in TC (from 258.9 ± 4.0 mg/dL to 212.7 ± 4.5 mg/dL, p < 0.001), LDL-C (from 173.8 ± 3.5 to 129.0 ± 4.5 mg/dL, p < 0.001), and TG (from 127.0 ± 12.2 to 117.0 ± 9.2, mg/dL, p = 0.012) concentrations, while HDL-C concentrations remained unchanged. There were no alterations in liver enzymes or symptoms of muscle pain in any subject. These promising results suggest that supplementation with this nutraceutical mixture favorably influences lipid concentrations during a short period of administration while exhibiting an excellent safety profile. Larger controlled studies are required to assess the potential for cardiovascular risk reduction with the above compound.
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