用于新冠肺炎筛查的金属组学和金属药物开发

IF 3.4 2区 化学 Q1 SPECTROSCOPY Atomic Spectroscopy Pub Date : 2021-08-29 DOI:10.46770/as.2021.805
Jiating Zhao, Liming Wang, L. Cui, Hongzhe Sun, Yuxi Gao, Bai Li, Yu-feng Li
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引用次数: 1

摘要

新冠肺炎疫情已在全球范围内造成严重威胁。因此,科学家们正在加大力度开发检测方法、抗病毒药物和疫苗,以分别诊断、治疗和预防新冠肺炎。尽管RT-PCR和抗原检测用于新冠肺炎的筛查,但存在许多缺点,包括成本高、处理时间长和假阴性结果。除了支持性护理外,尚未确定新冠肺炎的具体治疗方法。金属组学专注于系统研究金属/类金属离子及其物种与生物和生态系统中的基因、蛋白质、代谢产物和其他生物分子的相互作用和功能连接。它已被应用于各种癌症、神经退行性疾病、病毒感染的筛查和金属药物开发,具有高通量、低交叉感染风险、低成本和现成的优点。因此,我们建议将金属组学用于新冠肺炎的筛选和金属药物开发。并提出了一个可操作的工作方案。
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Metallomics for the Screening of COVID-19 and Metallodrug Development
The COVID-19 pandemic has led to severe threat globally. As a result, scientists are increasing their efforts in developing testing methods, antiviral drugs, and vaccines, to diagnose, treat, and defend against COVID-19 respectively. Although RT-PCR and antigen tests are used for the screening of COVID-19, there are many disadvantages including high cost, long processing time, and false-negative results. With the exception of supportive care, no specific treatment for COVID-19 has been established. Metallomics focuses on the systematic study of the interactions and functional connections of metallic/metalloid ions and their species with genes, proteins, metabolites, and other biomolecules within organisms and ecosystems. It has been applied in the screening of various cancers, neurodegenerative diseases, and viral infections and metallodrug development with the advantages of high throughput, low risk of cross-infection, low cost, and ready availability. Therefore, we proposed the use of metallomics for the screening and metallodrug development of COVID-19. An operational work scheme is also presented.
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来源期刊
Atomic Spectroscopy
Atomic Spectroscopy 物理-光谱学
CiteScore
5.30
自引率
14.70%
发文量
42
审稿时长
4.5 months
期刊介绍: The ATOMIC SPECTROSCOPY is a peer-reviewed international journal started in 1962 by Dr. Walter Slavin and now is published by Atomic Spectroscopy Press Limited (ASPL). It is intended for the rapid publication of both original articles and review articles in the fields of AAS, AFS, ICP-OES, ICP-MS, GD-MS, TIMS, SIMS, AMS, LIBS, XRF and related techniques. Manuscripts dealing with (i) instrumentation & fundamentals, (ii) methodology development & applications, and (iii) standard reference materials (SRMs) development can be submitted for publication.
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