Nafisat Oyewale MBBS , Danielle O'Neill MRCOG , San Soo Hoo MRCOG , Nabeel Salmons FRCPath
{"title":"Krukenberg肿瘤中的花状间充质/基质增殖;说明此潜在诊断缺陷的案例描述","authors":"Nafisat Oyewale MBBS , Danielle O'Neill MRCOG , San Soo Hoo MRCOG , Nabeel Salmons FRCPath","doi":"10.1016/j.ehpc.2020.200469","DOIUrl":null,"url":null,"abstract":"<div><p>Discrimination between primary ovarian neoplasia and ovarian metastases is important as their management and prognosis are markedly different. We hereby describe the case of a 39 year female who presented with bilateral ovarian masses. Histology of the ovaries predominantly showed a hypercellular and markedly oedematous ovarian stroma with features mimicking a sex-cord stromal tumour. Only with extensive tumour sampling were scant signet ring cells identified, allowing for the diagnosis of bilateral metastatic signet ring adenocarcinoma (Krukenberg tumour) to be made. Our case is used to illustrate and highlight the importance of good morphological assessment, adequate tumour sampling alongside the judicious use of immunohistochemistry and tinctorial staining in the evaluation of an ovarian mass in order to avoid misdiagnosis.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2020.200469","citationCount":"0","resultStr":"{\"title\":\"Florid mesenchymal/stromal proliferation in Krukenberg tumours; A case description illustrating this potential diagnostic pitfall\",\"authors\":\"Nafisat Oyewale MBBS , Danielle O'Neill MRCOG , San Soo Hoo MRCOG , Nabeel Salmons FRCPath\",\"doi\":\"10.1016/j.ehpc.2020.200469\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Discrimination between primary ovarian neoplasia and ovarian metastases is important as their management and prognosis are markedly different. We hereby describe the case of a 39 year female who presented with bilateral ovarian masses. Histology of the ovaries predominantly showed a hypercellular and markedly oedematous ovarian stroma with features mimicking a sex-cord stromal tumour. Only with extensive tumour sampling were scant signet ring cells identified, allowing for the diagnosis of bilateral metastatic signet ring adenocarcinoma (Krukenberg tumour) to be made. Our case is used to illustrate and highlight the importance of good morphological assessment, adequate tumour sampling alongside the judicious use of immunohistochemistry and tinctorial staining in the evaluation of an ovarian mass in order to avoid misdiagnosis.</p></div>\",\"PeriodicalId\":38075,\"journal\":{\"name\":\"Human Pathology: Case Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ehpc.2020.200469\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Human Pathology: Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214330020301188\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Pathology: Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214330020301188","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Florid mesenchymal/stromal proliferation in Krukenberg tumours; A case description illustrating this potential diagnostic pitfall
Discrimination between primary ovarian neoplasia and ovarian metastases is important as their management and prognosis are markedly different. We hereby describe the case of a 39 year female who presented with bilateral ovarian masses. Histology of the ovaries predominantly showed a hypercellular and markedly oedematous ovarian stroma with features mimicking a sex-cord stromal tumour. Only with extensive tumour sampling were scant signet ring cells identified, allowing for the diagnosis of bilateral metastatic signet ring adenocarcinoma (Krukenberg tumour) to be made. Our case is used to illustrate and highlight the importance of good morphological assessment, adequate tumour sampling alongside the judicious use of immunohistochemistry and tinctorial staining in the evaluation of an ovarian mass in order to avoid misdiagnosis.