超重或肥胖多囊卵巢综合征的高级治疗:一项前瞻性研究

Min Min , Xiangyan Ruan , Alfred O. Mueck
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引用次数: 1

摘要

目的探讨奥利司他联合降螺酮/炔雌醇片(DRSP/EE)对超重或肥胖多囊卵巢综合征(PCOS)患者的人体测量指标、性激素及肝肾功能指标的影响。方法选取2019年4月- 2020年1月首都医科大学附属北京妇产科医院妇科内分泌科75例体重指数(BMI)≥24 kg/m2的超重或肥胖多囊卵巢综合征(PCOS)患者,进行前瞻性、随机、开放标签对照研究。按入组顺序依次编号,随机分为两组,第一组50例,奥利司他加DRSP/EE;2组25例患者单独接受DRSP/EE治疗。两组患者在饮食和运动等生活方式的个性化、标准化管理和监测方面都得到了相同的综合干预。结果治疗3个月后,两组患者体重、腰围(WC)、臀围(HC)、BMI均显著降低(P <0.05)。组1体重、WC、HC、BMI下降幅度显著大于组2 (P <0.05)。两组患者游离睾酮和性激素结合球蛋白水平均有显著变化(P <0.05)。治疗3个月后两组肝肾功能指标比较差异无统计学意义(P >0.05)。结论据我们所知,本研究首次探讨了奥利司他联合DRSP/EE治疗超重或肥胖PCOS患者的效果,并与单独使用DRSP/EE的效果进行了比较。奥利司他联合DRSP/EE的减重效果优于单用DRSP/EE,为临床合理用药选择提供了依据。
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Advanced therapy of overweight or obese polycystic ovary syndrome: a prospective study

Objective

To investigate the effects of orlistat combined with drospirenone/ethinylestradiol tablets (DRSP/EE) on anthropometric indices, sexual hormones, hepatorenal function parameters of overweight or obese patients with polycystic ovary syndrome (PCOS).

Methods

75 overweight or obese PCOS patients [body mass index (BMI) ≥ 24 kg/m2] were recruited within the Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, from April 2019 to January 2020, for a prospective, randomized, open-labelled comparing study. They were numbered one by one according to the order of recruitement and randomly divided into two groups, group 1 included 50 patients, orlistat plus DRSP/EE; group 2 included 25 patients treated with DRSP/EE alone. Both groups got the same comprehensive intervention in terms of individualized, standardized managment and monitoring of life-style like diet and exercise. The changes of anthropometric indices, sexual hormones, hepatorenal function parameters before and after three months of treatment in the two groups were compared .

Results

After three months of treatment, body weight, waist circumference (WC), hip circumference (HC) and BMI of both groups were significantly decreased (P < 0.05). The decrease of body weight, WC, HC and BMI in group 1 was significantly greater than those in group 2 (P < 0.05). Free testosterone and sex hormone–binding globulin in both groups were significantly changed (P < 0.05). There was no significant difference in the hepatorenal function parameters between the two groups after three months treatment (P > 0.05).

Conclusion

To our knowledge our study is the first to investigate the effects of orlistat combined with DRSP/EE in overweight or obese PCOS patients comparing with the effect of using DRSP/EE alone. Orlistat combined with DRSP/EE was better than use DRSP/EE alone in getting weight loss, which provides an evidence for the choice of rational drug use in clinical practice.

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来源期刊
Global health journal (Amsterdam, Netherlands)
Global health journal (Amsterdam, Netherlands) Public Health and Health Policy
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5.00
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