新型中药抗菌凝胶治疗皮肤烧伤感染的处方与评价

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Journal of Reports in Pharmaceutical Sciences Pub Date : 2021-01-01 DOI:10.4103/jrptps.JRPTPS_100_20
M. Bagheri, Y. Shokoohinia, Zahra Pourmanouchehri, Fereshteh Jalilian, S. Khaledian, S. Mirzaie, L. Behbood
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引用次数: 1

摘要

由于抗生素耐药性的迅速发展,迫切需要替代战略来解决这一问题是不可避免的。本研究的目的是制备并评价含有指甲花和洋甘菊提取物的药用凝胶的抗菌作用。采用羟丙基甲基纤维素(HPMC)、羧甲基纤维素(CMC)和丙二醇(PEG)配制药物凝胶,并在37±2℃下测定制剂的物理性能。采用Folin-Ciocalteu法测定提取物总酚含量(TPC),以没食子酸(GA) mg / g提取物(Ex)表示。用Franz细胞装置考察了最佳配方中多酚类化合物的释放。最后采用圆盘扩散法评价最佳配方对金黄色葡萄球菌和铜绿假单胞菌两种病原菌的抑菌活性。结果表明,最佳配方在3个月内稳定。指甲花水提液、洋甘菊水醇提液的TPC分别为57.8、181.08、202.75 mg GA/g Ex。最佳配方中近80%的酚类化合物在4 h内释放,对金黄色葡萄球菌和铜绿假单胞菌的生长有抑制作用。该制剂具有良好的稳定性、粘度、均匀性、可挤压性和抗菌活性,可作为外用药物凝胶用于皮肤烧伤感染的治疗。
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Formulation and evaluation of the novel herbal antibacterial gel to the treatment of cutaneous burn infections
Due to the rapid development of antibiotic resistance, the strong need for alternative strategies to tackle this problem is inevitable. The objective of this study was to prepare and evaluate the antibacterial effects of a pharmaceutical gel containing herbal extracts including Lawsonia inermis (henna) and Matricaria chamomilla. Using hydroxypropyl methylcellulose (HPMC), carboxymethylcellulose (CMC), and propylene glycol (PEG), the pharmaceutical gel was formulated and the physical properties of the formulation were specified at 37 ± 2°C. The total phenolic content (TPC) of extracts was determined using the Folin–Ciocalteu method and expressed as mg gallaic acid (GA) per gram extract (Ex). The release of the polyphenol compounds from the optimum formulation was investigated using the Franz cell device. Eventually, the disc diffusion method was used to evaluate the antibacterial activity of optimum formulation against the two pathogenic bacteria strains Staphylococcus aureus and Pseudomonas aeruginosa. The results showed that the optimum formulation was stable at least for 3 months. The TPC of the aqueous extract of henna leaves, the hydroalcoholic extract of chamomile flowers, and the optimum formulation was 57.8, 181.08, and 202.75 mg GA/g Ex, respectively. Nearly 80% of the phenolic compounds in the optimum formulation were released over 4 h. The phenolic compounds have inhibitory effects on the growth of S. aureus and P. aeruginosa. On the basis of this finding, the formulation had excellent stability, viscosity, homogeneity, extrudability, and antibacterial activity which can be employed as a topical pharmaceutical gel in cutaneous burn infection treatment.
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来源期刊
Journal of Reports in Pharmaceutical Sciences
Journal of Reports in Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.40
自引率
0.00%
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0
期刊介绍: The Journal of Reports in Pharmaceutical Sciences(JRPS) is a biannually peer-reviewed multi-disciplinary pharmaceutical publication to serve as a means for scientific information exchange in the international pharmaceutical forum. It accepts novel findings that contribute to advancement of scientific knowledge in pharmaceutical fields that not published or under consideration for publication anywhere else for publication in JRPS as original research article. all aspects of pharmaceutical sciences consist of medicinal chemistry, molecular modeling, drug design, pharmaceutics, biopharmacy, pharmaceutical nanotechnology, pharmacognosy, natural products, pharmaceutical biotechnology, pharmacology, toxicology and clinical pharmacy.
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