泛驱动阴性与表皮生长因子受体突变对c期IA型肺腺癌磨玻璃样混浊的影响

IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Annals of Thoracic and Cardiovascular Surgery Pub Date : 2022-05-28 DOI:10.5761/atcs.oa.22-00058
Ming Li, Junjie Xi, Huan Zhang, Xing Jin, Jianrong Zhang, M. Feng, C. Zhan, Qun Wang
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引用次数: 2

摘要

目的:我们旨在验证具有磨玻璃样混浊(GGO)成分的临床(c)期IA肺腺癌的表皮生长因子受体(EGFR)突变的预后。方法:我们对226例经手术切除的带有GGO成分的c期IA肺腺癌进行了评估。终点为总生存期(OS)和无复发生存期(RFS)。Kaplan–Meier分析和对数秩检验用于估计生存差异。使用单变量和多变量Cox比例风险模型评估预后因素。结果:226例中,177例携带EGFR突变型腺癌,其中GGO组分。平均随访时间为54.4±1.2个月。EGFR突变组和野生型组之间的5年OS和RFS没有显著差异(5年OS 100%对94.3%,风险比[HR]0.276,P=0.168;5年RFS 94.7%对95.7%,HR0.873,P=0.864)。多变量Cox风险模型显示,放射学固体成分大小(P=0.010)和病理结阳性(P=0.036)是较差RFS的重要预测因素。结论:EGFR突变不是具有GGO成分的c期IA肺腺癌OS和RFS的预后因素。放射学实体成分大小和病理性淋巴结状况是RFS恶化的独立预后因素。
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Pan-Driver-Negatives versus Epidermal Growth Factor Receptor Mutants for C-Stage IA Lung Adenocarcinoma with Ground-Glass Opacity
Purpose: We aimed to verify the prognosis of epidermal growth factor receptor (EGFR) mutation of clinical (c)-stage IA lung adenocarcinoma with the ground-glass opacity (GGO) component. Methods: We evaluated 226 cases of surgically resected c-stage IA lung adenocarcinoma with GGO component. Endpoints were overall survival (OS) and recurrence-free survival (RFS). Kaplan–Meier analysis and the log-rank test were used to estimate the survival differences. Prognostic factors were assessed using the univariable and multivariable Cox proportional hazards model. Results: Among the 226 cases, 177 cases harbored the EGFR-mutant adenocarcinoma with the GGO component. The mean duration of follow-up time was 54.4 ± 1.2 months. The 5-year OS and RFS did not differ significantly between the EGFR-mutant and wild-type groups (5-year OS 100% vs. 94.3%, hazard ratio [HR] 0.276, P = 0.168; 5-year RFS 94.7% vs. 95.7%, HR 0.873, P = 0.864). Multivariable Cox hazard model revealed that radiologically solid component size (P = 0.010) and pathological node-positive (P = 0.036) were significant predictors of an inferior RFS. Conclusion: EGFR-mutant was not a prognostic factor of OS and RFS for c-stage IA lung adenocarcinoma with the GGO component. Radiologically solid component size and pathological lymph node status were independent prognostic factors of worse RFS.
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来源期刊
Annals of Thoracic and Cardiovascular Surgery
Annals of Thoracic and Cardiovascular Surgery CARDIAC & CARDIOVASCULAR SYSTEMS-SURGERY
CiteScore
2.80
自引率
0.00%
发文量
56
审稿时长
4-8 weeks
期刊介绍: Information not localized
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