{"title":"电子顺磁共振光谱法鉴定γ辐照乙酰唑胺中形成的自由基","authors":"Kerem Sütçü, Y. Emre Osmanoğlu","doi":"10.1007/s00723-023-01551-w","DOIUrl":null,"url":null,"abstract":"<div><p>In this study, spectroscopic, dosimetric and stability characteristics of free radicals formed in acetazolamide (ACE) sample as a result of gamma irradiation in the range of 0–15 kGy were determined using electron paramagnetic resonance (EPR) spectroscopy. For this purpose, by interpreting the spectra of the sample in the 0–100 mW microwave power region, it was determined that two different radicals were formed in the sample. The structures formed after irradiation were attributed to CH<sub>3</sub>OṄ-(radical I) and -OSOṄH (radical II) radicals. The g-values, hyperfine coupling constants and spectrum contribution ratios of these radicals contributing to the experimental spectrum were also calculated. It has been determined that radical II is quite stable both at high temperature and after a long storage period.\n</p></div>","PeriodicalId":469,"journal":{"name":"Applied Magnetic Resonance","volume":"54 8","pages":"737 - 750"},"PeriodicalIF":1.1000,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00723-023-01551-w.pdf","citationCount":"0","resultStr":"{\"title\":\"Identification of Free Radicals Formed in Gamma-Irradiated Acetazolamide Using Electron Paramagnetic Resonance Spectroscopy\",\"authors\":\"Kerem Sütçü, Y. Emre Osmanoğlu\",\"doi\":\"10.1007/s00723-023-01551-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this study, spectroscopic, dosimetric and stability characteristics of free radicals formed in acetazolamide (ACE) sample as a result of gamma irradiation in the range of 0–15 kGy were determined using electron paramagnetic resonance (EPR) spectroscopy. For this purpose, by interpreting the spectra of the sample in the 0–100 mW microwave power region, it was determined that two different radicals were formed in the sample. The structures formed after irradiation were attributed to CH<sub>3</sub>OṄ-(radical I) and -OSOṄH (radical II) radicals. The g-values, hyperfine coupling constants and spectrum contribution ratios of these radicals contributing to the experimental spectrum were also calculated. It has been determined that radical II is quite stable both at high temperature and after a long storage period.\\n</p></div>\",\"PeriodicalId\":469,\"journal\":{\"name\":\"Applied Magnetic Resonance\",\"volume\":\"54 8\",\"pages\":\"737 - 750\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-06-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s00723-023-01551-w.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Magnetic Resonance\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00723-023-01551-w\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSICS, ATOMIC, MOLECULAR & CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Magnetic Resonance","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.1007/s00723-023-01551-w","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, ATOMIC, MOLECULAR & CHEMICAL","Score":null,"Total":0}
Identification of Free Radicals Formed in Gamma-Irradiated Acetazolamide Using Electron Paramagnetic Resonance Spectroscopy
In this study, spectroscopic, dosimetric and stability characteristics of free radicals formed in acetazolamide (ACE) sample as a result of gamma irradiation in the range of 0–15 kGy were determined using electron paramagnetic resonance (EPR) spectroscopy. For this purpose, by interpreting the spectra of the sample in the 0–100 mW microwave power region, it was determined that two different radicals were formed in the sample. The structures formed after irradiation were attributed to CH3OṄ-(radical I) and -OSOṄH (radical II) radicals. The g-values, hyperfine coupling constants and spectrum contribution ratios of these radicals contributing to the experimental spectrum were also calculated. It has been determined that radical II is quite stable both at high temperature and after a long storage period.
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Applied Magnetic Resonance provides an international forum for the application of magnetic resonance in physics, chemistry, biology, medicine, geochemistry, ecology, engineering, and related fields.
The contents include articles with a strong emphasis on new applications, and on new experimental methods. Additional features include book reviews and Letters to the Editor.
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