Rui-Hong Chen, Fengling Song, Yu Gan, Ting-ting Li, L. Ye, Wei Jing Liu, Hua-feng Liu
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Autophagy and Transforming Growth Factor Beta1 in Renal Tubular Epithelia Cells
Transforming growth factor beta1 (TGF-β1) is regarded as the important factor in many fibrotic kidney diseases. Autophagy is a vital mechanism which maintains intracellular homeostasis in eukaryotic cells and involves in various renal physiologic and pathological processes. Current studies indicate that autophagy in renal tubular epithelial cells serves as a renoprotective mechanism which modulates the course of diverse kidney disease. Thus, this review aims to show the possible linkage between TGF-β1 and autophagy in the renal tubular epithelial cells. RevieW ARTiCLe
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