肠关节轴:口服益生菌改善骨关节炎

IF 3.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Traditional and Complementary Medicine Pub Date : 2024-01-01 DOI:10.1016/j.jtcme.2023.06.002
Uzma Amin , Rong Jiang , Shahid Masood Raza , Mengtian Fan , Li Liang , Naibo Feng , Xiaoli Li , Yuyou Yang , Fengjin Guo
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引用次数: 0

摘要

骨关节炎(OA)的病因是多因素的,其发病率在全球范围内不断增长。肠道微生物群塑造了我们的免疫系统,影响着健康和疾病的方方面面。利用益生菌治疗不同病症的想法十分普遍。关于肌肉骨骼疾病和健康,目前的数据缺乏了解宿主和微生物组之间相互作用的联系。我们报告说,嗜热菌、五味子乳杆菌(益生菌)和γ-氨基丁酸(GABA)在体内可预防骨关节炎,在体外可缓解 IL-1β 诱导的软骨细胞变化。我们研究了细菌处理后小鼠血清和小肠中 GABA 浓度的增加。治疗抑制了软骨的分解,使小鼠关节免于退化。此外,合成代谢标志物上调并减少了小鼠膝关节和软骨细胞中的炎症标志物。这项研究首次体现了 GABA 对关节和人类软骨细胞的软骨生成和软骨保护作用。这些数据为今后研究阐明 GABA 在调节软骨细胞增殖中的作用奠定了基础。这些发现为了解肠道-关节轴和 OA 治疗开辟了未来的视野。因此,益生菌/GABA疗法可以保护小鼠的OA关节,至少可以作为治疗骨关节炎的辅助疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Gut-joint axis: Oral Probiotic ameliorates Osteoarthritis

Osteoarthritis (OA) etiology is multifactorial, and its prevalence is growing globally. The Gut microbiota shapes our immune system and impacts all aspects of health and disease. The idea of utilizing probiotics to treat different conditions prevails. Concerning musculoskeletal illness and health, current data lack the link to understand the interactions between the host and microbiome. We report that S. thermophilus, L. pentosus (as probiotics), and γ-aminobutyric acid (GABA) harbour against osteoarthritis in vivo and alleviate IL-1β induced changes in chondrocytes in vitro. We examined the increased GABA concentration in mice's serum and small intestine content followed by bacterial treatment. The treatment inhibited the catabolism of cartilage and rescued mice joints from degradation. Furthermore, the anabolic markers upregulated and decreased inflammatory markers in mice knee joints and chondrocytes. This study is the first to represent GABA's chondrogenic and chondroprotective effects on joints and human chondrocytes. This data provides a foundation for future studies to elucidate the role of GABA in regulating chondrocyte cell proliferation. These findings opened future horizons to understanding the gut-joint axis and OA treatment. Thus, probiotic/GABA therapy shields OA joints in mice and could at least serve as adjuvant therapy to treat osteoarthritis.

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来源期刊
Journal of Traditional and Complementary Medicine
Journal of Traditional and Complementary Medicine Medicine-Complementary and Alternative Medicine
CiteScore
9.30
自引率
6.70%
发文量
78
审稿时长
66 days
期刊介绍: eJTCM is committed to publish research providing the biological and clinical grounds for using Traditional and Complementary Medical treatments as well as studies that demonstrate the pathophysiological and molecular/biochemical bases supporting the effectiveness of such treatments. Review articles are by invitation only. eJTCM is receiving an increasing amount of submission, and we need to adopt more stringent criteria to select the articles that can be considered for peer review. Note that eJTCM is striving to increase the quality and medical relevance of the publications.
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