血清抑制素A与妊娠结局的关系

Q4 Medicine pzshkhy blyny bn syn Pub Date : 2020-06-01 DOI:10.21859/AJCM.27.1.30
S. Alimohammadi, Forogh Sehat, J. Porolajal, M. Faryadras
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引用次数: 0

摘要

背景和目的:一些研究表明,生物标志物水平异常可能与不良妊娠结局有关。本研究旨在探讨血清抑制素A水平与妊娠结局之间的关系。材料和方法:这项回顾性队列研究是对伊朗哈马丹560名妊娠15至20周孕妇的抑制素A数据进行的。抑制素A水平低于0.5和高于2毫摩尔分别被认为低于和高于。根据出生体重、胎龄、Apgar评分、先兆子痫、宫内胎儿死亡和剖宫产对患者进行评估。计算受试者操作特征曲线水平,以检测不良妊娠并发症。数据在STATA软件(版本14)中进行统计分析。结果:在符合研究条件的孕妇中,33例(5.9%)病例因医疗记录文件不完整和不可用而被排除在外。在剩下的527名患者中,378名(71.7%)、26名(4.9%)和123名(23.3%)患者的抑制素A水平分别正常、低和高。与正常或低水平的患者相比,血清抑制素A水平较高的患者患先兆子痫、低出生体重和早产的风险更高(P 0.05)。
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Relationship between Serum Inhibin A and Pregnancy Outcomes
Background and Objective: Some studies have shown that abnormal levels of biomarkers may be associated with adverse pregnancy outcomes. This study aimed to investigate the association between serum levels of Inhibin A and the outcomes of pregnancy. Materials and Methods: This retrospective cohort study was conducted on the data obtained from the Inhibin A of 560 pregnant women at 15 to 20 weeks of gestation in Hamadan, Iran. The levels of Inhibin A less than 0.5 and higher than 2 mmol were considered below and high, respectively. The patients were assessed in terms of birth weight, gestational age, Apgar score, preeclampsia, intrauterine fetal death, and cesarean section. The receiver operating characteristic curve level was calculated to detect adverse pregnancy complications. The data were statistically analyzed in STATA software (version 14). Results: Out of the pregnant women eligible for the study, 33 (5.9%) cases were excluded due to incomplete medical record files and unavailability. Of the remaining 527 patients, 378 (71.7%), 26 (4.9%), and 123 (23.3%) ones had normal, low, had high Inhibin A levels, respectively. Patients with higher serum Inhibin A levels had a higher risk of preeclampsia, low birth weight, and prematurity, compared to those with normal or low levels (P˂0.05). Conclusion: Based on the findings of the present study, high levels of Inhibin A at 15 to 20 weeks of gestation can be associated with the risk of preeclampsia, low birth weight, and prematurity.
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来源期刊
CiteScore
0.30
自引率
0.00%
发文量
16
审稿时长
8 weeks
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