发现血管内皮生长因子在血管系统发育中的基本作用

IF 2.6 Q2 Medicine Mechanisms of Development Pub Date : 2019-12-01 DOI:10.1016/j.mod.2019.103579

Domenico Ribatti

{"title":"发现血管内皮生长因子在血管系统发育中的基本作用","authors":"Domenico Ribatti","doi":"10.1016/j.mod.2019.103579","DOIUrl":null,"url":null,"abstract":"<div><p>In the 1980', vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) was identified and shown to be a key regulator of endothelial cell proliferation and migration, and vascular permeability. The essential role of VEGF and of VEGF receptors (VEGFRs) for the development of the embryonic vascular system has been established via gene disruption studies. This article summarizes the fundamental contributions that have been made in the early days of angiogenesis research to define the involvement of VEGF/VEGFRs in the developing vasculature.</p></div>","PeriodicalId":49844,"journal":{"name":"Mechanisms of Development","volume":"160 ","pages":"Article 103579"},"PeriodicalIF":2.6000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mod.2019.103579","citationCount":"14","resultStr":"{\"title\":\"The discovery of the fundamental role of VEGF in the development of the vascular system\",\"authors\":\"Domenico Ribatti\",\"doi\":\"10.1016/j.mod.2019.103579\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In the 1980', vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) was identified and shown to be a key regulator of endothelial cell proliferation and migration, and vascular permeability. The essential role of VEGF and of VEGF receptors (VEGFRs) for the development of the embryonic vascular system has been established via gene disruption studies. This article summarizes the fundamental contributions that have been made in the early days of angiogenesis research to define the involvement of VEGF/VEGFRs in the developing vasculature.</p></div>\",\"PeriodicalId\":49844,\"journal\":{\"name\":\"Mechanisms of Development\",\"volume\":\"160 \",\"pages\":\"Article 103579\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2019-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.mod.2019.103579\",\"citationCount\":\"14\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mechanisms of Development\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0925477319301352\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mechanisms of Development","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0925477319301352","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 14

摘要

20世纪80年代，血管内皮生长因子(vascular endothelial growth factor, VEGF)又称血管通透性因子(vascular permeability factor, VPF)被发现，并被证明是内皮细胞增殖、迁移和血管通透性的关键调节因子。VEGF及其受体(VEGFRs)在胚胎血管系统发育中的重要作用已通过基因破坏研究得到证实。本文总结了血管生成研究早期所做的基本贡献，以确定VEGF/ vegfr在血管系统发育中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

The discovery of the fundamental role of VEGF in the development of the vascular system

In the 1980', vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) was identified and shown to be a key regulator of endothelial cell proliferation and migration, and vascular permeability. The essential role of VEGF and of VEGF receptors (VEGFRs) for the development of the embryonic vascular system has been established via gene disruption studies. This article summarizes the fundamental contributions that have been made in the early days of angiogenesis research to define the involvement of VEGF/VEGFRs in the developing vasculature.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Mechanisms of Development 生物-发育生物学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

12.4 weeks

期刊介绍： Mechanisms of Development is an international journal covering the areas of cell biology and developmental biology. In addition to publishing work at the interphase of these two disciplines, we also publish work that is purely cell biology as well as classical developmental biology. Mechanisms of Development will consider papers in any area of cell biology or developmental biology, in any model system like animals and plants, using a variety of approaches, such as cellular, biomechanical, molecular, quantitative, computational and theoretical biology. Areas of particular interest include: Cell and tissue morphogenesis Cell adhesion and migration Cell shape and polarity Biomechanics Theoretical modelling of cell and developmental biology Quantitative biology Stem cell biology Cell differentiation Cell proliferation and cell death Evo-Devo Membrane traffic Metabolic regulation Organ and organoid development Regeneration Mechanisms of Development does not publish descriptive studies of gene expression patterns and molecular screens; for submission of such studies see Gene Expression Patterns.

期刊最新文献

Editorial Board Publisher's note Outside Front Cover Regulatory functions of gga-miR-218 in spermatogonial stem cells meiosis by targeting Stra8 Improved early development potence of in vitro fertilization embryos by treatment with tubacin increasing acetylated tubulin of matured porcine oocytes