Seyed Mohammad-Hossein Shetab-Boushehri, A. Hosseini, J. Rafinejad, Alireza Ebadollahi-Natanzi, S. V. Shetab-Boushehri
{"title":"东方黄蜂毒液囊提取物对T47D和MCF10A乳腺细胞株的细胞毒、坏死、凋亡和自噬特性","authors":"Seyed Mohammad-Hossein Shetab-Boushehri, A. Hosseini, J. Rafinejad, Alireza Ebadollahi-Natanzi, S. V. Shetab-Boushehri","doi":"10.1080/15569543.2021.2007404","DOIUrl":null,"url":null,"abstract":"Abstract Honey bee, Apis mellifera, is classified in the Apidae family while wasps and hornets are classified in the Vespidae family. The present work has investigated and measured cytotoxic, necrotic, apoptotic, and autophagic effects of venom sac extract (VSE) of Vespa orientalis hornet on T47D (cancerous) and MCF10A (normal) breast cell lines. The results showed that the VSE of oriental hornet displays a stronger necrotic effect than apoptotic and autophagic effects in a given concentration on both cell lines. They also indicated that necrotic, apoptotic, and autophagic effects of VSE of oriental hornets are more prominent on T47D than MCF10A cells. Moreover, the necrotic effect of VSE on oriental hornets is more potent than its apoptotic and autophagic effects. The results also showed that the VSE of oriental hornets kills T47D (cancerous) cells more rapidly than MCF10A (normal) cells.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"7 - 17"},"PeriodicalIF":3.3000,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Cytotoxic, necrotic, apoptotic, and autophagic properties of venom sac extract of Vespa orientalis in T47D and MCF10A breast cell lines\",\"authors\":\"Seyed Mohammad-Hossein Shetab-Boushehri, A. Hosseini, J. Rafinejad, Alireza Ebadollahi-Natanzi, S. V. Shetab-Boushehri\",\"doi\":\"10.1080/15569543.2021.2007404\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Honey bee, Apis mellifera, is classified in the Apidae family while wasps and hornets are classified in the Vespidae family. The present work has investigated and measured cytotoxic, necrotic, apoptotic, and autophagic effects of venom sac extract (VSE) of Vespa orientalis hornet on T47D (cancerous) and MCF10A (normal) breast cell lines. The results showed that the VSE of oriental hornet displays a stronger necrotic effect than apoptotic and autophagic effects in a given concentration on both cell lines. They also indicated that necrotic, apoptotic, and autophagic effects of VSE of oriental hornets are more prominent on T47D than MCF10A cells. Moreover, the necrotic effect of VSE on oriental hornets is more potent than its apoptotic and autophagic effects. The results also showed that the VSE of oriental hornets kills T47D (cancerous) cells more rapidly than MCF10A (normal) cells.\",\"PeriodicalId\":23211,\"journal\":{\"name\":\"Toxin Reviews\",\"volume\":\"42 1\",\"pages\":\"7 - 17\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2021-12-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxin Reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/15569543.2021.2007404\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxin Reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15569543.2021.2007404","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"TOXICOLOGY","Score":null,"Total":0}
Cytotoxic, necrotic, apoptotic, and autophagic properties of venom sac extract of Vespa orientalis in T47D and MCF10A breast cell lines
Abstract Honey bee, Apis mellifera, is classified in the Apidae family while wasps and hornets are classified in the Vespidae family. The present work has investigated and measured cytotoxic, necrotic, apoptotic, and autophagic effects of venom sac extract (VSE) of Vespa orientalis hornet on T47D (cancerous) and MCF10A (normal) breast cell lines. The results showed that the VSE of oriental hornet displays a stronger necrotic effect than apoptotic and autophagic effects in a given concentration on both cell lines. They also indicated that necrotic, apoptotic, and autophagic effects of VSE of oriental hornets are more prominent on T47D than MCF10A cells. Moreover, the necrotic effect of VSE on oriental hornets is more potent than its apoptotic and autophagic effects. The results also showed that the VSE of oriental hornets kills T47D (cancerous) cells more rapidly than MCF10A (normal) cells.
期刊介绍：
Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
