纳米二氧化钛暴露和自噬:一项系统综述和荟萃分析

IF 3.3 4区医学 Q2 TOXICOLOGY Toxin Reviews Pub Date : 2022-06-07 DOI:10.1080/15569543.2022.2084419

Li Li, Ruoyun Dong, Tao Liu, Yaqian Yang, Hongmei Chang, Xiaojia Meng, Yaxin Deng, Qianqian Wang, Yiman Zhao, Guanling Song, Yunhua Hu

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引用次数: 0

摘要

摘要纳米二氧化钛(nano-TiO2)广泛应用于人类生活的许多方面。然而，关于纳米tio2暴露对自噬的影响，目前还没有一致的结论。因此，通过系统回顾和荟萃分析来揭示纳米tio2是否会诱导自噬失调。结果表明，LC3 II、Beclin-1蛋白和LC3 II/LC3 I蛋白比值显著升高，而p62蛋白变化不显著。亚组分析显示，当纳米tio2处理时间为10 ~ 24 h时，p62和Beclin-1蛋白显著升高。纳米tio2可以诱导自噬失调，长时间暴露后导致自噬停滞。

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Nano-titanium dioxide exposure and autophagy: a systematic review and meta-analysis

Abstract Nano-titanium dioxide (nano-TiO2) is widely used in many aspects of human life. However, there are still inconsistent conclusions about the effects of nano-TiO2 exposure on autophagy. Therefore, a systematic review and meta-analysis were used to reveal whether nano-TiO2 induces dysregulation of autophagy. The results showed that LC3 II, Beclin-1 protein, and LC3 II/LC3 I protein ratio were significantly increased, but p62 protein was insignificantly changed. Subgroup analyses showed that p62 and Beclin-1 protein were increased significantly when the treatment time of nano-TiO2 was >24 h. Nano-TiO2 can induce dysregulation of autophagy and cause stagnation of autophagy after prolonged exposure.

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来源期刊

Toxin Reviews 医学-毒理学

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.