Ultra-thin 2D bimetallic MOF nanosheets for highly sensitive and stable detection of glucose in sweat for dancer

The measurement of glucose concentration in sweat is expected to replace the existing blood glucose detection, which realize the effective way of non-invasive monitoring of human glucose concentration in dancing. High precision glucose detection can be achieved by adjusting the electrode material of the sensor. Thus, in this work, the bimetallic organic frameworks (bi-MOFs) materials containing Mn and Ni ions (NiMn-MOF) with ultrathin nanosheets have been exquisitely designed. The ultrathin nanosheet and heterogeneous metal ions in the structure optimize the electronic structure, which improves the electrical conductivity of MOFs. The success of the preparation strategy leads the good electrocatalytic performance of NiMn-MOF for glucose detection. Detailedly, NiMn-MOF shows high sensitivity of 1576 μA mM⁻¹ cm⁻² in the linear range from 0 to 0.205 mM and the wide linear region of 0.255–2.655 mM and 3.655–5.655 mM were also observed. In addition, the high repeatability, reproductivity, long-term stability and ultra-low limited of detection (LOD, 0.28 μM, S/N = 3) provide foundation for the practical sensor application of this NiMn-MOF nanosheets. Remarkably, as designed NiMn-MOF sensor can accurately measure glucose in sweat showing great potential in the field of wearable glucose monitoring during dancing.