{"title":"缺血再灌注过程中促炎细胞因子对心脏的保护作用","authors":"Li-Sha Li, Hong Wu, Shu-Xia Wang, Sui-xin Liu, Le-Qing Lin, Da-Ke Qi","doi":"10.4103/2470-7511.334402","DOIUrl":null,"url":null,"abstract":"Myocardial ischemia and reperfusion (I/R) lead to an inflammatory response that causes cardiac injury and remodeling. However, increasing evidence suggests this is an over-simplified view. Several proinflammatory cytokines, including tumor necrosis factor-α, interleukin-1α, interleukin-6, macrophage migration inhibitory factor and D-dopachrome tautomerase have been shown to improve cell survival and compensate energy deprivation during I/R. This review summarizes the recent findings that support protective role of proinflammatory cytokines against cardiac injury during acute I/R, as well as therapeutic ramifications of these findings.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"6 1","pages":"246 - 255"},"PeriodicalIF":0.0000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Cardiac protective effects of proinflammatory cytokines during ischemia-reperfusion\",\"authors\":\"Li-Sha Li, Hong Wu, Shu-Xia Wang, Sui-xin Liu, Le-Qing Lin, Da-Ke Qi\",\"doi\":\"10.4103/2470-7511.334402\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Myocardial ischemia and reperfusion (I/R) lead to an inflammatory response that causes cardiac injury and remodeling. However, increasing evidence suggests this is an over-simplified view. Several proinflammatory cytokines, including tumor necrosis factor-α, interleukin-1α, interleukin-6, macrophage migration inhibitory factor and D-dopachrome tautomerase have been shown to improve cell survival and compensate energy deprivation during I/R. This review summarizes the recent findings that support protective role of proinflammatory cytokines against cardiac injury during acute I/R, as well as therapeutic ramifications of these findings.\",\"PeriodicalId\":52908,\"journal\":{\"name\":\"Cardiology Plus\",\"volume\":\"6 1\",\"pages\":\"246 - 255\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardiology Plus\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/2470-7511.334402\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiology Plus","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/2470-7511.334402","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Cardiac protective effects of proinflammatory cytokines during ischemia-reperfusion
Myocardial ischemia and reperfusion (I/R) lead to an inflammatory response that causes cardiac injury and remodeling. However, increasing evidence suggests this is an over-simplified view. Several proinflammatory cytokines, including tumor necrosis factor-α, interleukin-1α, interleukin-6, macrophage migration inhibitory factor and D-dopachrome tautomerase have been shown to improve cell survival and compensate energy deprivation during I/R. This review summarizes the recent findings that support protective role of proinflammatory cytokines against cardiac injury during acute I/R, as well as therapeutic ramifications of these findings.
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