{"title":"X染色体连锁凋亡抑制蛋白、高迁移率组box-1蛋白和Vimentin在胃癌组织中的表达及意义","authors":"Yong Xu, Rongchao Ying","doi":"10.3760/CMA.J.ISSN.1001-9030.2020.01.041","DOIUrl":null,"url":null,"abstract":"Objective \nTo explore the expression and significance of X chromosome linked inhibitor of apoptosis protein (XIAP), high mobility group box-1 protein (HMGB1) and Vimentin in gastric cancer. \n \n \nMethods \nThe expression levels of XIAP, HMGB1 and Vimentin in 84 cases of gastric cancer and adjacent normal tissues were detected by immunohistochemical in June 2016 to January 2019 in Hangzhou Dajiangdong Hospital, and the relationship between the expression of XIAP, HMGB1 and Vimentin and clinicopathological parameters was analyzed. \n \n \nResults \nThe positive expression rate of XIAP in gastric cancer (65.48%, 55/84) was higher than that in adjacent normal tissues (17.86%, 15/84, χ2=50.837, P<0.05). The positive expression rate of HMGB1 in gastric cancer tissues (75.00%, 63/84) was higher than that in adjacent normal tissues (9.52%, 8/84, , χ2=73.791, P<0.05). The positive expression rate of Vimentin in gastric cancer tissues (70.23%, 59/84) was higher than that in adjacent normal tissues (20.24%, 17/84, χ2=42.384, P<0.05). The positive rate of XIAP, HMGB1 and Vimentin in stage Ⅲ-Ⅳ of gastric cancer was significantly higher than that in stage Ⅰ-Ⅱ (χ2=12.574, 9.821, P<0.05). The positive expression rate of XIAP, HMGB1 and Vimentin in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis (χ2=23.290, 25.337, P<0.05). The positive rate of XIAP, HMGB1 and Vimentin in gastric cancer tissues were not correlated with age, sex and degree of differentiation. There was positive correlation between XIAP and HMGB1 (r=0.597, P<0.01), between XIAP and Vimentin (r=0.621, P<0.01), and between HMGB1 and Vimentin (r=0.634, P<0.01). \n \n \nConclusion \nXIAP, HMGB1 and Vimentin were highly expressed in gastric cancer tissues, which could be used as predictors of the occurrence and malignancy of gastric cancer. \n \n \nKey words: \nX chromosome linked inhibitor of apoptosis protein; High mobility group box-1 protein; Vimentin; Gastric cancer","PeriodicalId":10065,"journal":{"name":"中华实验外科杂志","volume":"37 1","pages":"141-143"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Expression and significance of X chromosome linked inhibitor of apoptosis protein, high mobility group box-1 protein and Vimentin in gastric cancer\",\"authors\":\"Yong Xu, Rongchao Ying\",\"doi\":\"10.3760/CMA.J.ISSN.1001-9030.2020.01.041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo explore the expression and significance of X chromosome linked inhibitor of apoptosis protein (XIAP), high mobility group box-1 protein (HMGB1) and Vimentin in gastric cancer. \\n \\n \\nMethods \\nThe expression levels of XIAP, HMGB1 and Vimentin in 84 cases of gastric cancer and adjacent normal tissues were detected by immunohistochemical in June 2016 to January 2019 in Hangzhou Dajiangdong Hospital, and the relationship between the expression of XIAP, HMGB1 and Vimentin and clinicopathological parameters was analyzed. \\n \\n \\nResults \\nThe positive expression rate of XIAP in gastric cancer (65.48%, 55/84) was higher than that in adjacent normal tissues (17.86%, 15/84, χ2=50.837, P<0.05). The positive expression rate of HMGB1 in gastric cancer tissues (75.00%, 63/84) was higher than that in adjacent normal tissues (9.52%, 8/84, , χ2=73.791, P<0.05). The positive expression rate of Vimentin in gastric cancer tissues (70.23%, 59/84) was higher than that in adjacent normal tissues (20.24%, 17/84, χ2=42.384, P<0.05). The positive rate of XIAP, HMGB1 and Vimentin in stage Ⅲ-Ⅳ of gastric cancer was significantly higher than that in stage Ⅰ-Ⅱ (χ2=12.574, 9.821, P<0.05). The positive expression rate of XIAP, HMGB1 and Vimentin in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis (χ2=23.290, 25.337, P<0.05). The positive rate of XIAP, HMGB1 and Vimentin in gastric cancer tissues were not correlated with age, sex and degree of differentiation. There was positive correlation between XIAP and HMGB1 (r=0.597, P<0.01), between XIAP and Vimentin (r=0.621, P<0.01), and between HMGB1 and Vimentin (r=0.634, P<0.01). \\n \\n \\nConclusion \\nXIAP, HMGB1 and Vimentin were highly expressed in gastric cancer tissues, which could be used as predictors of the occurrence and malignancy of gastric cancer. \\n \\n \\nKey words: \\nX chromosome linked inhibitor of apoptosis protein; High mobility group box-1 protein; Vimentin; Gastric cancer\",\"PeriodicalId\":10065,\"journal\":{\"name\":\"中华实验外科杂志\",\"volume\":\"37 1\",\"pages\":\"141-143\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华实验外科杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1001-9030.2020.01.041\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华实验外科杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1001-9030.2020.01.041","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Expression and significance of X chromosome linked inhibitor of apoptosis protein, high mobility group box-1 protein and Vimentin in gastric cancer
Objective
To explore the expression and significance of X chromosome linked inhibitor of apoptosis protein (XIAP), high mobility group box-1 protein (HMGB1) and Vimentin in gastric cancer.
Methods
The expression levels of XIAP, HMGB1 and Vimentin in 84 cases of gastric cancer and adjacent normal tissues were detected by immunohistochemical in June 2016 to January 2019 in Hangzhou Dajiangdong Hospital, and the relationship between the expression of XIAP, HMGB1 and Vimentin and clinicopathological parameters was analyzed.
Results
The positive expression rate of XIAP in gastric cancer (65.48%, 55/84) was higher than that in adjacent normal tissues (17.86%, 15/84, χ2=50.837, P<0.05). The positive expression rate of HMGB1 in gastric cancer tissues (75.00%, 63/84) was higher than that in adjacent normal tissues (9.52%, 8/84, , χ2=73.791, P<0.05). The positive expression rate of Vimentin in gastric cancer tissues (70.23%, 59/84) was higher than that in adjacent normal tissues (20.24%, 17/84, χ2=42.384, P<0.05). The positive rate of XIAP, HMGB1 and Vimentin in stage Ⅲ-Ⅳ of gastric cancer was significantly higher than that in stage Ⅰ-Ⅱ (χ2=12.574, 9.821, P<0.05). The positive expression rate of XIAP, HMGB1 and Vimentin in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis (χ2=23.290, 25.337, P<0.05). The positive rate of XIAP, HMGB1 and Vimentin in gastric cancer tissues were not correlated with age, sex and degree of differentiation. There was positive correlation between XIAP and HMGB1 (r=0.597, P<0.01), between XIAP and Vimentin (r=0.621, P<0.01), and between HMGB1 and Vimentin (r=0.634, P<0.01).
Conclusion
XIAP, HMGB1 and Vimentin were highly expressed in gastric cancer tissues, which could be used as predictors of the occurrence and malignancy of gastric cancer.
Key words:
X chromosome linked inhibitor of apoptosis protein; High mobility group box-1 protein; Vimentin; Gastric cancer
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