一种Cu(II)基配位聚合物:脑卒中的催化性能和治疗活性

IF 1.8 4区 化学 Q3 POLYMER SCIENCE Designed Monomers and Polymers Pub Date : 2022-06-09 DOI:10.1080/15685551.2022.2086396
Pengfei Gao, Ji-rong Liu
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引用次数: 0

摘要

摘要用铜盐与4,7-二甲基-1,10-菲罗啉和对苯二甲酸的混合配体水热反应制备了Cu(II)配位聚合物[Cu3(Hmbdc)2(mbdc)2(dmphen)2]n (1,h2mbdc =异邻苯二甲酸,dmphen = 4,7-二甲基-1,10-菲罗啉)。并通过Fenton法对刚果红进行降解,评价了1的催化活性,在100 min降解效率达到95.8%。其次,评价了化合物对冲程的应用价值,同时探讨了相关机理。首先用酶联免疫吸附法检测试剂盒测定释放到血浆中的肿瘤坏死因子-α和重组大鼠IL-1β的含量。此外,还采用实时逆转录-聚合酶链反应法检测了脑血管内皮细胞HMGB1/TLR4信号通路的激活情况。
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A Cu(II)-based coordination polymer: catalytic properties and treatment activity on stroke
ABSTRACT A fresh Cu(II) coordination polymer, i.e., [Cu3(Hmbdc)2(mbdc)2(dmphen)2]n (1, H2mbdc = isophthalic acid, dmphen = 4,7-dimethyl-1,10-phenanthroline), has been generated with the hydrothermal reactions between Cu salts and the mixed ligands of 4,7-dimethyl-1,10-phenanthroline and isophthalic acid. Moreover, the catalytic activity of 1 was evaluated via degrading the Congo red with a method of Fenton with an excellent degradation efficiency of 95.8% at 100 min. Next, the application value of compound on stroke was assessed, and the related mechanisms were explored at the same time. First of all, the tumor necrosis factor-α and recombinant rat IL-1β content released into the plasma were determined with enzyme-linked immunosorbent assay detection kit. Besides, the activation of the HMGB1/TLR4 signaling pathway activation in cerebral vascular endothelial cells was also determined with real-time reverse transcription–polymerase chain reaction assay.
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来源期刊
Designed Monomers and Polymers
Designed Monomers and Polymers 化学-高分子科学
CiteScore
3.30
自引率
0.00%
发文量
28
审稿时长
2.1 months
期刊介绍: Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications
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