空肠胃肠道间质瘤(GIST): 1例危及生命的急诊报告

M. Saad, I. Hajj, E. Saikaly
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摘要

小肠胃肠道间质瘤(GIST)是一种罕见的肿瘤,估计发生频率为10-20/L百万人群,通常发生在生命的60年中。GIST,主要是大于4cm的GIST,有广泛的表现,从腹部不适和腹胀到胃肠道大出血引起的腹部紧急情况,上覆粘膜的压力性坏死和溃疡是导致胃肠道出血的主要机制。危及生命的出血是一种罕见的初始表现。在胃肠道出血的广泛鉴别诊断中,空肠GIST是最罕见的病因之一。由于它的位置,因此无法通过内窥镜检查进行识别,因此很难诊断。因此,计算机断层扫描(CT)血管造影术被认为是识别胃肠道出血部位的关键,有助于诊断GIST。这种紧急表现的主要治疗方法是切除,如果及时切除,会产生良好的临床结果。在此,我们报告了一例46岁男性患者,在放射学栓塞失败后,出现空肠GIST大量胃肠道出血,导致血液动力学不稳定,需要通过小肠切除进行大量输血。在极少数情况下,GIST表现为大量胃肠道出血,需要入院治疗和紧急干预。在我们的病例中,早期的多学科方法表现为介入放射学和手术团队的参与,这是成功管理我们患者的基石,在所有上消化道大出血病例中都应该考虑。
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Jejunal gastrointestinal stromal tumor (GIST): a case report presenting as life threatening emergency
Small bowel gastrointestinal stromal tumor (GIST) is an uncommon tumor, with an estimated frequency of 10–20/L million population, occurring usually in the 6 decade of life. GISTs, mainly ones larger than 4 cm have a wide range of presentations from abdominal discomfort and bloating to abdominal emergencies due to massive gastrointestinal (GI) hemorrhage, with pressure necrosis and ulceration of the overlying mucosa is the main mechanism leading to GI hemorrhage. Life-threatening hemorrhage is a rare initial presentation. Among the wide differential diagnosis for GI bleeding, jejunal GIST is one of the rarest etiologies. Due to its location and hence the inability to identify by endoscopy it is difficult to diagnose. From here, computed tomography (CT) angiography is considered essential for identification of the site of GI bleed, which aids in diagnosis of GIST. The mainstay treatment for this emergent presentation is resection, which if done in a timely manner results in a good clinical outcome. Herein, we report a case of a 46-yearold male patient presenting with massive GI bleed from jejunal GIST, leading to hemodynamic instability, requiring massive transfusion protocol managed by small bowel resection, after failure of radiologic embolization. In rare instances GISTs present as massive GI bleeding necessitating admission to the hospital and urgent interference. In our case the early multidisciplinary approach manifested by involvement of interventional radiology with the surgical team was the cornerstone in the successful management of our patient and should be considered in all cases of massive upper GI bleeding.
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