E. Hasković, S. Herenda, Zehra Halilović, S. Unčanin, Denis Hasković, Ena Deljkić
{"title":"氯雷他定和钙离子对过氧化氢酶氧化还原酶活性影响的研究","authors":"E. Hasković, S. Herenda, Zehra Halilović, S. Unčanin, Denis Hasković, Ena Deljkić","doi":"10.2174/1573408016999200817173859","DOIUrl":null,"url":null,"abstract":"\n\nThe Spectrophotometric method is one of the most suitable analytical techniques\nfor testing the activity of enzymes under the influence of various factors.\n\n\n\nThe effect of H1-antihistamines of loratadine and calcium ions on enzyme catalase under\nin vitro conditions was investigated in this paper.\n\n\n\n It has been shown that loratadine is a partial inhibitor of catalase, but this\neffect is diminished in the presence of calcium ions. Calcium as well as other cations are important\nfor many biological and cellular functions. The kidneys play a central role in the homeostasis of these\nions. The activity of the catalase enzyme under the given conditions, the type of inhibition, and the\nkinetic parameters of the enzyme reaction were determined.\n\n\n\nWe concluded that loratadine is a partially competitive inhibitor.\n","PeriodicalId":35405,"journal":{"name":"Current Enzyme Inhibition","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigation of the Effect of Loratadine and Calcium Ions on Oxidoreductase Activity of Catalase Enzyme\",\"authors\":\"E. Hasković, S. Herenda, Zehra Halilović, S. Unčanin, Denis Hasković, Ena Deljkić\",\"doi\":\"10.2174/1573408016999200817173859\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nThe Spectrophotometric method is one of the most suitable analytical techniques\\nfor testing the activity of enzymes under the influence of various factors.\\n\\n\\n\\nThe effect of H1-antihistamines of loratadine and calcium ions on enzyme catalase under\\nin vitro conditions was investigated in this paper.\\n\\n\\n\\n It has been shown that loratadine is a partial inhibitor of catalase, but this\\neffect is diminished in the presence of calcium ions. Calcium as well as other cations are important\\nfor many biological and cellular functions. The kidneys play a central role in the homeostasis of these\\nions. The activity of the catalase enzyme under the given conditions, the type of inhibition, and the\\nkinetic parameters of the enzyme reaction were determined.\\n\\n\\n\\nWe concluded that loratadine is a partially competitive inhibitor.\\n\",\"PeriodicalId\":35405,\"journal\":{\"name\":\"Current Enzyme Inhibition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-08-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Enzyme Inhibition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1573408016999200817173859\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Enzyme Inhibition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1573408016999200817173859","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
Investigation of the Effect of Loratadine and Calcium Ions on Oxidoreductase Activity of Catalase Enzyme
The Spectrophotometric method is one of the most suitable analytical techniques
for testing the activity of enzymes under the influence of various factors.
The effect of H1-antihistamines of loratadine and calcium ions on enzyme catalase under
in vitro conditions was investigated in this paper.
It has been shown that loratadine is a partial inhibitor of catalase, but this
effect is diminished in the presence of calcium ions. Calcium as well as other cations are important
for many biological and cellular functions. The kidneys play a central role in the homeostasis of these
ions. The activity of the catalase enzyme under the given conditions, the type of inhibition, and the
kinetic parameters of the enzyme reaction were determined.
We concluded that loratadine is a partially competitive inhibitor.
期刊介绍：
Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.
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