IL-27p28基因多态性与变应性鼻炎易感性的关系

Farzaneh Koohyanizadeh, Seyed Hamidreza Mortazavi, Farhad Salari, Sara Falahi, Alireza Rezaiemanesh, A. Gorgin Karaji
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引用次数: 0

摘要

白细胞介素-27 (Interleukin-27, IL-27)是一种由EBI3和p28两个亚基组成的细胞因子,是调节TCD4 +细胞分化的重要介质,在免疫相关疾病中起重要作用。本研究旨在阐明IL-27p28基因单核苷酸多态性(snp)与血清IL-27水平和变应性鼻炎(AR)风险之间的潜在关联。材料与方法本研究纳入130例AR患者和130例健康人。为了评估IL-27p28基因snp (rs153109和rs181206)与AR风险的相关性,采用聚合酶链反应-限制性片段长度多态性方法。采用酶联免疫吸附法测定AR患者和健康人血清IL-27水平。结果IL-27p28基因多态性(rs153109和rs181206)与AR风险和血清IL-27水平无显著关系。然而,我们的研究结果显示,AR患者血清IL-27水平(342±299 pg/mL)显著低于健康对照组(455±274 pg/mL) (p = 0.02)。结论IL-27p28 snp (rs181206和rs153109)与AR易感性无关,但血清IL-27水平降低可能与AR的发生有关。
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Association between IL-27p28 gene polymorphisms and susceptibility to allergic rhinitis
Background Interleukin-27 (IL-27) is a cytokine composed of two subunits, EBI3 and p28, which is an important mediator in regulating the differentiation of TCD4 + cells and plays an important role in immune-related disorders. This study aimed to elucidate the potential association of single nucleotide polymorphisms (SNPs) of the IL-27p28 gene with serum IL-27 levels and the risk of allergic rhinitis (AR). Materials and methods The study included 130 patients with AR and 130 healthy individuals. To evaluate the association between IL-27p28 gene SNPs (rs153109 and rs181206) and the risk of AR, the Polymerase chain reaction-restriction fragment length polymorphism method was used. Enzyme-linked immunosorbent assay was also used to determine the serum level of IL-27 in patients with AR and healthy individuals. Results Our results did not show a significant relationship between IL-27p28 gene polymorphisms (rs153109 and rs181206) with the risk of AR and serum IL-27 levels. However, our results indicated that the serum level of IL-27 in patients with AR (342 ± 299 pg/mL) was significantly lower than the healthy controls (455 ± 274 pg/mL) (p = 0.02). Conclusion Our findings suggested that IL-27p28 SNPs (rs181206 and rs153109) are not associated with susceptibility to AR, but decreased serum IL-27 levels may be associated with the development of AR.
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来源期刊
CiteScore
4.00
自引率
0.00%
发文量
88
审稿时长
15 weeks
期刊介绍: International Journal of Immunopathology and Pharmacology is an Open Access peer-reviewed journal publishing original papers describing research in the fields of immunology, pathology and pharmacology. The intention is that the journal should reflect both the experimental and clinical aspects of immunology as well as advances in the understanding of the pathology and pharmacology of the immune system.
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