A case of colon adenocarcinoma with neuroendocrine differentiation

The present case report describes a 59-year-old man with colon adenocarcinoma with neuroendocrine differentiation. The initial presentation was defect in the visual field and an elevated lesion in the retina. Positron emission tomography, contrast-enhanced computed tomography, and colonoscopy led to the diagnosis of descending colon cancer with metastasis to the bones, adrenal glands, choroid, and regional and distant lymph nodes. Despite administering CapeOX (capecitabine plus oxaliplatin) treatment after performing palliative surgery for colonic obstruction, ileus occurred due to the rapid growth of the dissemination and remnant metastatic lymph nodes. Thus, further treatment was not possible. Although adenocarcinoma with neuroendocrine differentiation in the colon is a rare disease, its aggressive nature and poor prognosis highlight the need for further research and development of standard therapy.