锦葵和锦葵对高脂饮食诱导的高脂血症大鼠肝功能和心功能的影响

IF 1 Q4 FOOD SCIENCE & TECHNOLOGY Nutrition & Food Science Pub Date : 2021-10-29 DOI:10.1108/nfs-03-2021-0099
Abimbola Abiodun Adeyemi-Doro, S. Salawu, A. Akindahunsi
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引用次数: 0

摘要

目的研究两种绿叶蔬菜(红叶和银菜)对高脂饮食诱导的高脂血症大鼠肝脏生物标志物[谷丙转氨酶(ALT)和天冬氨酸转氨酶(AST)]、心脏生物标志物[肌酸激酶(CK)和乳酸脱氢酶(LDH)]和心脏组织病理学的影响,以评价其作为功能性食品的价值。设计/方法/方法:试验饲粮分为对照饲粮(CD)、高脂肪饲粮(HFD)、高脂肪饲粮加焯过的银根(HCB)、高脂肪饲粮加未焯过的银根(HCU)、高脂肪饲粮加焯过的银根(HGB)和高脂肪饲粮加未焯过的银根(HGU)。选用白化雄性大鼠75只(体重180-200 g)。这些动物被分成15组,每组5只白化老鼠。1组、2组和3组分别饲喂CD、HFD和HFD加阿托瓦斯汀(5 mg/kg b.w)。4、5、6组分别饲喂5%、10%、15%六氯环己烷。第7、8和9组分别饲喂5%、10%和15% HCU,第10、11和12组分别饲喂5%、10%和15% HGB,第13、14和15组分别饲喂5%、10%和15% HGU。结果与HFD相比,添加植物性物质显著降低了ALT、AST、CK和LDH活性(p = 0.05)。然而,组织学检查显示没有病理病变,只有15%的蔬菜包含。原创性/价值:本研究认为,在饮食中添加银芹和扁豆,特别是添加量为15%时,可作为治疗高脂血症及相关并发症的功能性食品。
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Effects of Gongronema latifolium Benth and Celosia argentea Linn supplemented diet on the hepatic and cardiac functions of high-fat diet-induced hyperlipidemic rats
Purpose The purpose of this study is to assess the effects of two green leafy vegetables (Gongronema latifolium and Celosia argentea) on the hepatic biomarkers [Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST)], cardiac biomarkers [Creatine Kinase (CK) and Lactate Dehydrogenase (LDH)] and histopathology of the heart of high-fat diet-induced hyperlipidemic rats, with the aim of evaluating the vegetables as functional foods. Design/methodology/approach Experimental diets consisted of Control Diet (CD), High-Fat Diet (HFD), High-Fat Diet with Blanched Celosia argentea (HCB), High-Fat Diet with Unblanched Celosia argentea (HCU), High-Fat diet with Blanched Gongronema latifolium (HGB) and High-Fat Diet with Unblanched Gongronema latifolium (HGU). Seventy-five albino male rats (weighing 180–200 g) were used. The animals were divided into 15 groups of five albino rats each. Animals in Groups 1, 2 and 3 were fed with CD, HFD only and HFD with Atorvastin (5 mg/kg b.w), respectively. Animals in Groups 4, 5 and 6 were fed with 5, 10 and 15% HCB, respectively. Animals in Groups 7, 8 and 9 were fed with 5, 10 and 15% HCU, respectively, whereas animals in Groups 10, 11 and 12 were fed with 5, 10 and 15% HGB, respectively, and animals in Groups 13, 14 and 15 were fed with 5, 10 and 15% diet-inclusion of HGU, respectively. Findings The incorporation of the vegetal matter into the diet brought about a significant reduction (p = 0.05) in the activities of ALT, AST, CK and LDH when compared with HFD. However, the histological examination showed no pathological lesion, only at 15% inclusion of the vegetables. Originality/value The paper established that the incorporation of Celosia argentea and Gongronema latifolium into diet, most especially at 15% inclusion, may serve as functional food in the management of hyperlipidemia and associated complications.
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来源期刊
Nutrition & Food Science
Nutrition & Food Science FOOD SCIENCE & TECHNOLOGY-
CiteScore
2.80
自引率
8.30%
发文量
85
期刊介绍: Nutrition & Food Science* (NFS) is an international, double blind peer-reviewed journal offering accessible and comprehensive coverage of food, beverage and nutrition research. The journal draws out the practical and social applications of research, demonstrates best practice through applied research and case studies and showcases innovative or controversial practices and points of view. The journal is an invaluable resource to inform individuals, organisations and the public on modern thinking, research and attitudes to food science and nutrition. NFS welcomes empirical and applied research, viewpoint papers, conceptual and technical papers, case studies, meta-analysis studies, literature reviews and general reviews which take a scientific approach to the following topics: -Attitudes to food and nutrition -Healthy eating/ nutritional public health initiatives, policies and legislation -Clinical and community nutrition and health (including public health and multiple or complex co-morbidities) -Nutrition in different cultural and ethnic groups -Nutrition during pregnancy, lactation, childhood, and young adult years -Nutrition for adults and older people -Nutrition in the workplace -Nutrition in lower and middle income countries (incl. comparisons with higher income countries) -Food science and technology, including food processing and microbiological quality -Genetically engineered foods -Food safety / quality, including chemical, physical and microbiological analysis of how these aspects effect health or nutritional quality of foodstuffs
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