CRP多态性与糖尿病肾病易感性的关系病例对照研究

IF 0.8 Q4 GENETICS & HEREDITY Meta Gene Pub Date : 2022-02-01 DOI:10.1016/j.mgene.2021.101009

Molud Ghanbari , Amir Hossein Miladipour , Sayyed Mohammad Hossein Ghaderian , Zahra Fazeli , Shirin Rajabi , Masoumeh Rajabibazl

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引用次数: 0

摘要

糖尿病肾病(Diabetic nephropathy, DN)被认为是终末期肾病(end-stage renal disease, ESRD)的主要病因，患者死亡率高。DN患者死于心血管疾病的风险很高。c反应蛋白(CRP)基因在肾脏和心血管疾病的发病机制中起重要作用。本研究的目的是探讨两种CRP多态性rs2794521和rs1800947与DN风险之间的关系。纳入75例DN患者、50例糖尿病患者和50例健康对照。采用PCR-RFLP对rs2794521和rs1800947进行基因分型。分析结果显示，rs2794521与DN易感性显著相关，与糖尿病无关。未观察到rs1800947与DN风险之间的关联。这些数据提示rs2794521可能在DN的病因学中发挥作用。

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Association between CRP polymorphisms and susceptibility to the diabetic nephropathy; A case-control study

Diabetic nephropathy (DN) was considered as the major cause of end-stage renal disease (ESRD) with the high mortality rate in the affected patients. Patients with DN are at high risk of death from cardiovascular diseases. C-reactive protein (CRP) gene has been known to be effective in the pathogenesis of renal and cardiovascular disease. The aim of the present study was to investigate the association between two CRP polymorphisms, rs2794521 and rs1800947, and risk of DN. Seventy-five patients with DN, fifty patients with diabetic mellitus and fifty healthy controls were enrolled. The genotyping of rs2794521 and rs1800947 were done by using PCR-RFLP. The analysis of the results indicated that rs2794521 was significantly associated with susceptibility to DN but no diabetic mellitus. No association was observed between rs1800947 and the DN risk. The obtained data suggested that rs2794521 may play a role in the etiology of DN.

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来源期刊

Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.