生物治疗严重银屑病对外周血树突状细胞的影响

IF 5.5 3区材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2023-12-01 Epub Date: 2023-08-13 DOI:10.1111/sji.13321

Aleksandra Petrovic, Lisa Lynn Ten Bergen, Silje Michelsen Solberg, Irene Sarkar, Brith Bergum, Richard Davies, Roland Jonsson, Silke Appel

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引用次数: 0

摘要

在使用抗肿瘤坏死因子药物英夫利西单抗（infiximab）、依那西普（etanercept）、抗IL-17A secukinumab和抗IL12/IL-23 ustekinumab治疗前（T1）和治疗12个月后（T2），通过流式细胞术对无寻常型银屑病（PsO；N = 23）或伴有银屑病关节炎（PsA；N = 15）的外周血树突状细胞（DC）群进行深入免疫分型。与健康供体（38 人）相比，PsA 患者的树突状细胞亚群 pDC、cDC1 和 cDC2 的频率较低，治疗后除 pDC 外，其他亚群均恢复正常。相比之下，PsO 患者仅显示出较低的 pDC 频率，但在治疗后恢复正常。图由 BioRender.com 绘制。

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Biological treatment in severe psoriasis: Influence on peripheral blood dendritic cells.

In-depth immunophenotyping by flow cytometry of peripheral blood dendritic cell (DC) populations of psoriasis vulgaris without (PsO; N = 23) or with psoriatic arthritis (PsA; N = 15), before (T1) and after 12 months (T2) therapy with the anti-TNF drugs infliximab, etanercept, the anti-IL-17A secukinumab and the anti-IL12/IL-23 ustekinumab. Compared to healthy donors (N = 38), patients with PsA displayed lower frequencies of dendritic cell subsets pDC, cDC1 and cDC2, which were normalized following treatment except pDC. In contrast, patients with PsO only displayed lower frequencies of pDC which were normalized following treatment. Figure created with BioRender.com.

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.