沙特阿拉伯卡西姆地区糖尿病患者中丙型肝炎病毒感染的患病率

IF 0.7 Q4 MICROBIOLOGY Journal of Pure and Applied Microbiology Pub Date : 2023-09-02 DOI:10.22207/jpam.17.3.37
Muneerah Hamad Aldubaie, Prarthana M. Suryavamshi, Uma M. Irfan, Hamad A. Al-Hamed, T. AlMogbel, Ahmad Almatroudi, Faris A Alrumaihi, K. Allemailem
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引用次数: 0

摘要

据报道,世界范围内与丙型肝炎病毒(HCV)感染相关的糖尿病(DM)患病率具有较高的发病率和死亡率。丙型肝炎的发病率每年约为300万至400万例,与此同时,糖尿病的发病率也在惊人地增加。世界卫生组织(世卫组织)明确指出,到2030年,糖尿病将成为第七大死亡原因。最近的一些重要报道表明,丙型肝炎病毒与糖尿病之间的联系日益密切。丙型肝炎病毒感染导致肝脂肪变性和快速胰岛素抵抗,这反过来又增加了肝纤维化和肝细胞癌的危险因素。本研究旨在研究沙特阿拉伯王国卡西姆地区HCV与糖尿病之间的关系,以及与HCV感染相关的不同危险因素。共采集糖尿病和非糖尿病患者的血液样本634份。首先用酶联免疫吸附试验(ELISA)筛选这些血液样本是否感染HCV,再用TaqMan HCV定量试验确认阳性样本,并估计不同样本的病毒载量。糖尿病患者HCV患病率为2.5%,与DM呈正相关(RR= 1.24, OR= 1.77),但无统计学意义。然而,女性糖尿病患者的HCV患病率与男性有显著差异(p<0.05)。行为因素对HCV感染无显著影响。本研究提示HCV与DM呈正相关,性别是HCV与DM的关联因素。更大样本量的进一步研究对于正确评估HCV和DM之间的时间关系具有重要意义。
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Prevalence of Hepatitis C Viral Infection among Diabetes Mellitus Patients in Qassim Region, Saudi Arabia
The worldwide prevalence of Diabetes Mellitus (DM) associated with Hepatitis C Virus (HCV) infection are reported with higher rates of morbidity and mortality. The frequency of HCV is approximately 3-4 million cases each year and in parallel the incidence of DM is increasing alarmingly. World Health Organization (WHO) has specified that DM will be the 7th leading cause of mortality by 2030. The increasing association between HCV and DM has been indicated by some significant reports recently. HCV infection leads to hepatic steatosis and rapid insulin resistance, which in turn upsurges the risk factors for hepatic fibrosis and hepatocellular carcinoma. This study is designed to examine the association between HCV and DM, and different risk factors associated with HCV infection in Qassim region, Kingdom of Saudi Arabia (KSA). A total of 634 blood samples were obtained from diabetic and non-diabetic patients. These blood samples were first screened for HCV infection by enzyme-linked immunosorbent assay (ELISA) and positive samples were again confirmed by TaqMan HCV quantitative test and the viral load in different samples was estimated. The HCV prevalence was identified as 2.5% in diabetic patients with a positive association between HCV and DM (RR= 1.24, OR= 1.77) which is not significant statistically. However, the HCV prevalence among diabetic females was significantly different from males (p<0.05). The behavioural factors had no significant impact to acquire HCV infection. This study indicated a positive association between HCV and DM. Gender was an association factor in the HCV and DM status. Further studies with larger sample size is significant to properly assess the temporal relationship between HCV and DM.
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来源期刊
Journal of Pure and Applied Microbiology
Journal of Pure and Applied Microbiology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MICROBIOLOGY
CiteScore
2.00
自引率
0.00%
发文量
266
审稿时长
11 months
期刊介绍: Journal of Pure and Applied Microbiology (JPAM) is a peer-reviewed, open access international journal of microbiology aims to advance and disseminate research among scientists, academics, clinicians and microbiologists around the world. JPAM publishes high-quality research in all aspects of microbiology in both online and print form on quarterly basis.
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