单细胞转录组分析观察早期肺癌发生与肿瘤微环境

IF 4.5 2区医学 Q1 ONCOLOGY Translational Oncology Pub Date : 2021-07-29 DOI:10.21203/rs.3.rs-735382/v1

Eun Young Kim, Y. Cha, Sang Hoon Lee, Sukin Jeong, Y. Choi, D. Moon, Sungsoo Lee, Y. Chang

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引用次数: 6

摘要

亮点•Tregs导致从不吸烟者早期肺癌癌症的免疫逃避TME。•γδT和NK细胞的耗竭和B细胞的浸润始于TME早期。•早期癌症细胞的特征是表面活性剂途径失调CAFs显示出抑制血管形成的基因集的富集。在肿瘤组织中，尖端状内皮细胞开始被未成熟的内皮细胞取代。

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Early lung carcinogenesis and tumor microenvironment observed by single-cell transcriptome analysis

Highlights • Tregs lead immune-evasive TME of early lung cancer of never smoker.• Depletion of γδT and NK cells and infiltration of B cells begins in early TME.• Early lung cancer cells were characterized by dysregulated surfactant pathway.• CAFs show enrichment of gene sets that inhibit vascular formation. In tumor tissue, tip-like endothelial cells begin to be replaced with immature ones.

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来源期刊

Translational Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

7.20

自引率

2.00%

发文量

314

审稿时长

6-12 weeks

期刊介绍： Translational Oncology publishes the results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of oncology patients. Translational Oncology will publish laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer. Peer reviewed manuscript types include Original Reports, Reviews and Editorials.