Eun Young Kim, Y. Cha, Sang Hoon Lee, Sukin Jeong, Y. Choi, D. Moon, Sungsoo Lee, Y. Chang
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Early lung carcinogenesis and tumor microenvironment observed by single-cell transcriptome analysis
Highlights • Tregs lead immune-evasive TME of early lung cancer of never smoker.• Depletion of γδT and NK cells and infiltration of B cells begins in early TME.• Early lung cancer cells were characterized by dysregulated surfactant pathway.• CAFs show enrichment of gene sets that inhibit vascular formation. In tumor tissue, tip-like endothelial cells begin to be replaced with immature ones.
期刊介绍：
Translational Oncology publishes the results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of oncology patients. Translational Oncology will publish laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer. Peer reviewed manuscript types include Original Reports, Reviews and Editorials.
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