快速亚赫兹恒电位/恒流生物阻抗测量使用混沌振荡器

IF 3 4区医学 Q3 ENGINEERING, BIOMEDICAL Biomedical Microdevices Pub Date : 2022-11-09 DOI:10.1007/s10544-022-00641-z

Abdulwadood Al-Ali, Ahmed Elwakil, Brent Maundy, Sohaib Majzoub

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引用次数: 0

摘要

利用传统的扫频法或其他窄带周期激励信号测量超低频(亚赫兹)生物阻抗谱需要相当长的时间。在这项工作中，提出了一种基于宽带混沌信号的阻抗测量技术，并在\(10\,mHz-1\,Hz\)频率范围内进行了实验验证。该技术在恒电位和恒流模式下进行了测试，首先使用商用组件，然后使用65纳米CMOS技术设计和制造的增强型Howland电流泵。与使用研究级Biologic VSP-300电化学站进行的测量相比，对水果样品评估了所提出技术的准确性。

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Fast Sub-Hz potentiostatic/galvanostatic bio-impedance measurements using chaotic oscillators

The measurement of bio-impedance spectra at ultra low frequencies (sub-Hz) is known to require a considerably long time with the classical frequency-sweep method or other narrow-band periodic excitation signals. In this work, an impedance measurement technique based on using wide-band chaotic signals is proposed and experimentally validated over the frequency range \(10\,mHz-1\,Hz\). The technique was tested in both potentiostatic and galvanostatic modes, first using commercial components and then using an enhanced Howland current pump designed and fabricated in a 65nm CMOS technology. The accuracy of the proposed technique was assessed on fruit samples compared to measurements conducted using a research-grade Biologic VSP-300 electro-chemical station.

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来源期刊

Biomedical Microdevices 工程技术-工程：生物医学

CiteScore

6.90

自引率

3.60%

发文量

审稿时长

6 months

期刊介绍： Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.