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引用次数: 3
摘要
DNA G-四链体（G4s）是在富含鸟嘌呤的序列中形成的非经典二级结构。在人类基因组中，G4s存在于基因启动子和端粒等调控区域，以控制复制、转录和端粒延长。在细胞背景下，有几种被称为G4结合蛋白（G4BP）的蛋白质与G4s相互作用，锚定、稳定和/或解开它们。这些蛋白质可能在内源性G4景观及其相关功能的调节中发挥不同的关键作用。本综述从G4BP的靶点和功能方面总结了目前关于G4BP的文献，为生物体内G4s的调节提供了最新的见解。
DNA G-Quadruplex-Binding Proteins: An Updated Overview
DNA G-quadruplexes (G4s) are non-canonical secondary structures formed in guanine-rich sequences. Within the human genome, G4s are found in regulatory regions such as gene promoters and telomeres to control replication, transcription, and telomere lengthening. In the cellular context, there are several proteins named as G4-binding proteins (G4BPs) that interact with G4s, either anchoring upon, stabilizing, and/or unwinding them. These proteins may play different key roles in the regulation of the endogenous G4 landscape and its associated functions. The present review summarizes the current literature on G4BPs in terms of their targets and functions, providing updated insights into the regulation of G4s in living organisms.
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