水痘-带状疱疹病毒对宿主细胞信号通路的调节

3区 医学 Q2 Medicine Current topics in microbiology and immunology Pub Date : 2023-01-01 DOI:10.1007/82_2021_251
Nandini Sen, Ann M Arvin
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引用次数: 0

摘要

宿主与病原体的相互作用涉及通过关键细胞网络进行复杂的由内向外和由外向内的信号传递,而这些信号传递决定着疾病的结局。磷酸肌酸 3- 激酶(PI3K)/Akt 通路是调节多种细胞功能的关键连接点,而磷酸化-Akt(pAkt)经常被发现在癌细胞中具有构成性活性,类似于磷酸化-STAT3。在本章中,我们将讨论 VZV 感染细胞中 PI3K/Akt 通路的调控以及包括 p53 在内的其他通路的调控,与 pAkt 和 pSTAT3 不同,p53 引导细胞走向凋亡。在 VZV 感染过程中,促凋亡因子和抗凋亡因子激活的微妙时空平衡可能为病毒在人类宿主体内复制和致病提供了最佳环境。
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Modulation of Host Cell Signaling Pathways by Varicella-Zoster Virus.

Host-pathogen interactions involve complex inside-out and outside-in signal transmission through critical cellular networks that dictate disease outcomes. The phosphoinositide 3-kinase (PI3K)/Akt pathway is a pivotal junction that regulates several cell functions, and phospho-Akt (pAkt) is often found to be constitutively active in cancer cells, similar to phospho-STAT3. In this chapter, we discuss the regulation of PI3K/Akt pathway in VZV infected cells and of other pathways including p53 which, unlike pAkt and pSTAT3, directs cells towards apoptosis. The fine spatio-temporal balance of activation of pro- and anti-apoptotic factors during VZV infection likely provides an optimum environment for the virus to replicate and cause disease in the human host.

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来源期刊
CiteScore
5.60
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: The review series Current Topics in Microbiology and Immunology provides a synthesis of the latest research findings in the areas of molecular immunology, bacteriology and virology. Each timely volume contains a wealth of information on the featured subject. This review series is designed to provide access to up-to-date, often previously unpublished information.
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