向Richard Lerner（1938–2021）致敬，他鼓励采用糖生物学方法开发广谱抗病毒药物

IF 2.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Israel Journal of Chemistry Pub Date : 2023-07-06 DOI:10.1002/ijch.202300086

Constantina Fotinou, Raymond A. Dwek

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摘要

理查德·勒纳(Richard Lerner)是20世纪一位富有远见的博学之士;医生、化学家、免疫学家、发明家和新科学领域的创始人。为了纪念他的一生和科学成就，我们讨论了他与牛津大学和糖生物学研究所的联系，并讨论了我们在宿主糖蛋白折叠途径及其抑制如何导致广谱抗病毒药物方面的研究数据。这种针对宿主开发抗病毒疗法的方法具有对许多病毒有效的优势，因此可用于防止新的流行病成为大流行。

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A Tribute to Richard Lerner (1938–2021) who Encouraged a Glycobiology Approach to a Broad-Spectrum Antiviral

Richard Lerner was a visionary polymath of the 20^th century; a medical doctor, chemist, immunologist, inventor, and founder of new scientific fields. As a tribute to his life and scientific achievements, we discuss his connection with Oxford University and the Glycobiology Institute and we discuss our research data on the host glycoprotein folding pathway and how its inhibition can lead to broad spectrum antiviral drugs. This host targeting approach for developing antiviral therapies has the advantage of being effective against many viruses, therefore can be used to prevent new epidemics to become pandemics.

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来源期刊

Israel Journal of Chemistry 化学-化学综合

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The fledgling State of Israel began to publish its scientific activity in 1951 under the general heading of Bulletin of the Research Council of Israel, which quickly split into sections to accommodate various fields in the growing academic community. In 1963, the Bulletin ceased publication and independent journals were born, with Section A becoming the new Israel Journal of Chemistry. The Israel Journal of Chemistry is the official journal of the Israel Chemical Society. Effective from Volume 50 (2010) it is published by Wiley-VCH. The Israel Journal of Chemistry is an international and peer-reviewed publication forum for Special Issues on timely research topics in all fields of chemistry: from biochemistry through organic and inorganic chemistry to polymer, physical and theoretical chemistry, including all interdisciplinary topics. Each topical issue is edited by one or several Guest Editors and primarily contains invited Review articles. Communications and Full Papers may be published occasionally, if they fit with the quality standards of the journal. The publication language is English and the journal is published twelve times a year.

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