理解“大气”,个人大气暴露:综合方法(预印本)

Hari Bhimaraju, Nitish Nag, Vaibhav Pandey, Ramesh C. Jain
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引用次数: 0

摘要

背景现代环境健康研究广泛关注室外空气污染物及其对公众健康的影响。然而,对监测和提高个人室内空气质量的研究却很少。暴露组学领域包括人类环境暴露及其对健康的影响。这种暴露的一个子集与大气暴露有关,称为“大气体”。大气体在健康中发挥着关键作用,对DNA、代谢、皮肤完整性和肺部健康有着重要影响。目的本工作旨在开发一种低成本、全面的测量系统,用于收集和分析大气因素。本研究探讨了大气体在公共卫生个性化和预防性护理中的意义。方法介绍并演示了一个基于物联网微控制器的系统。该系统收集实时室内空气质量数据,并将其发布到云端,以便立即访问。结果与预先校准的商业设备相比,实验结果的空气质量测量精度为90%,并证明了生活方式与空气质量之间的直接相关性。结论量化个体大气是推进个性化健康、医学研究和流行病学研究的重要一步。这项工作的两个主要目标是将大气体作为一个可测量的概念,并演示如何使用低成本的电子设备来实现它。通过实现公共规模的大气测量,这项工作也为公共卫生研究开辟了潜在的新方向。研究人员现在将有数据来模拟室内空气污染物对个人、社区和特定人口健康的影响,从而为预测和预防疾病提供新的方法。
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Understanding “Atmosome”, the Personal Atmospheric Exposome: Comprehensive Approach (Preprint)
BACKGROUND Modern environmental health research extensively focuses on outdoor air pollutants and their effects on public health. However, research on monitoring and enhancing individual indoor air quality is lacking. The field of exposomics encompasses the totality of human environmental exposures and its effects on health. A subset of this exposome deals with atmospheric exposure, termed the “atmosome.” The atmosome plays a pivotal role in health and has significant effects on DNA, metabolism, skin integrity, and lung health. OBJECTIVE The aim of this work is to develop a low-cost, comprehensive measurement system for collecting and analyzing atmosomic factors. The research explores the significance of the atmosome in personalized and preventive care for public health. METHODS An internet of things microcontroller-based system is introduced and demonstrated. The system collects real-time indoor air quality data and posts it to the cloud for immediate access. RESULTS The experimental results yield air quality measurements with an accuracy of 90% when compared with precalibrated commercial devices and demonstrate a direct correlation between lifestyle and air quality. CONCLUSIONS Quantifying the individual atmosome is a monumental step in advancing personalized health, medical research, and epidemiological research. The 2 main goals in this work are to present the atmosome as a measurable concept and to demonstrate how to implement it using low-cost electronics. By enabling atmosome measurements at a communal scale, this work also opens up potential new directions for public health research. Researchers will now have the data to model the impact of indoor air pollutants on the health of individuals, communities, and specific demographics, leading to novel approaches for predicting and preventing diseases.
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