K. S. Tenkov, M. V. Dubinin, A. A. Semenova, K. N. Belosludtsev
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Effect of Methyltriclosan on the Functioning of Isolated Rat Liver Mitochondria and Permeability of Liposomal Membranes
Effects of methyltriclosan, a biodegradation product of the antimicrobial agent triclosan, on the functional parameters of rat liver mitochondria were studied. It was found that methyltriclosan inhibits the activity of complexes II and IV of the respiratory chain. This causes a decrease in the rate of oxygen consumption by mitochondria in states 3 and 3UDNP. Methyltriclosan was shown to increase the rate of hydrogen peroxide production by rat liver mitochondria. In addition, methyltriclosan induces permeabilization of both mitochondrial membranes and the liposome membranes. Methyltriclosan, in contrast to triclosan, has a milder effect on organelles and their membranes. Possible mechanisms of methyltriclosan effects on mitochondria and liposomes are discussed.
期刊介绍：
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.
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