微球:一种持续结肠靶向药物递送的新方法

Q2 Pharmacology, Toxicology and Pharmaceutics Drug Delivery Letters Pub Date : 2023-05-01 DOI:10.2174/2210303113666230501204329
S. Chopade, Vaibhavi Jaunjalkar
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引用次数: 0

摘要

结肠靶向给药是治疗包括结肠癌和炎症性肠病(IBD)在内的疾病的一个研究领域,其目标是在最小的全身损伤下提供局部治疗。近几十年来,全球结肠问题的患病率增加,要求更多的局部治疗结肠疾病,这将导致开发更有效和安全的药物方案。在开发结肠给药配方时,考虑结肠的生理特征和疾病部位周围的环境是至关重要的。从肠道中部到肠道,胃肠道在运动、液体体积、酶活性和pH值方面都会发生动态变化。目前的研究重点是具有自由流动特性的可生物降解聚合物或基于蛋白质的微球,其粒径为5200 nm,与传统的结肠靶向给药系统相比具有多种优势。在药物通过GIT转运过程中,多糖保持其完整性并抑制药物释放。然而,当它接触到结肠液体时,就会受到厌氧微生物的攻击,被囚禁的药物就会被释放出来。本文综述了微球的制备方法和表征方法,以及微球的体内外研究方法。
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Microspheres: A Novel approach for Sustained Colon Targeted Drug Delivery
Colon targeted medication delivery is a field of study for disorders including colon cancer and inflammatory bowel disease (IBD), with the goal of delivering localised therapy with minimal systemic damage. In recent decades, the global prevalence of colonic problems has increased, demanding more local treatment of colonic disorders, which will lead to the development of more effective and safe pharmaceutical regimens. When developing a formulation for colonic administration, it's critical to consider both the physiological characteristics of the colon and the environment surrounding the disease site (s). The GI tract experiences dynamic changes in motility, fluid volume, enzyme activity, and pH from the middle to the intestine. The current review focuses on Biodegradable polymers or protein‑based microspheres having free‑flowing properties and particle size 5200 nm have a variety of advantages over conventional colon targeted drug delivery systems. During drug transit through the GIT, polysaccharides maintain their integrity and inhibit drug release. When it comes into contact with colonic fluid, however, it is attacked by anaerobic microbes, and the imprisoned medication is released. In this review, several methods of microsphere formulation and characterization were investigated along with its in vitro and in vivo study methodology.
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来源期刊
Drug Delivery Letters
Drug Delivery Letters Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
CiteScore
1.70
自引率
0.00%
发文量
30
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