COVID-19和雌激素在免疫反应中的作用

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Russian Open Medical Journal Pub Date : 2023-06-27 DOI:10.15275/rusomj.2023.0207

I. Dovzhikova, I. Andrievskaya

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引用次数: 0

摘要

截至2022年6月，我们在各种数据库中使用关键词搜索（雌激素和新冠肺炎）进行了一项研究。所有文章都用英文发表。在新冠肺炎大流行的背景下，在疾病的过程和结果中发现了性别差异。这篇综述的目的是总结新冠肺炎中基于性别的差异的潜在机制，重点是雌激素的作用。本文讨论了雌激素在病毒感染免疫反应中的作用。综述的单独章节专门讨论雌激素对先天和适应性免疫的影响。我们得出的结论是，未来的研究有很大的潜力来解读激素对人类生理和免疫反应的影响，以解释人类致病反应的异质性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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COVID-19 And The Role Of Estrogen In The Immune Response

We conducted a study using the keyword search (estrogens and COVID-19) in various databases through June 2022. All articles were published in English. In the context of the COVID-19 pandemic, gender differences were found in the course and outcomes of the disease. The goal of this review was to summarize the knowledge of the mechanisms underlying gender-based differences in COVID-19, with a focus on the role of estrogens. The article discusses the involvement of estrogen in the implementation of the immune response to viral infection. Separate sections of the review are dedicated to the effect of estrogens on innate and adaptive varieties of immunity. We concluded that there is great potential for future research on deciphering the effect of hormones on human physiology and immune responses to explain the heterogeneity of human pathogenic responses.

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来源期刊

Russian Open Medical Journal MEDICINE, GENERAL & INTERNAL-

CiteScore

0.90

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0.00%

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期刊介绍： Russian Open Medical Journal (RusOMJ) (ISSN 2304-3415) is an international peer reviewed open access e-journal. The website is updated quarterly with the RusOMJ’s latest original research, clinical studies, case reports, reviews, news, and comment articles. This Journal devoted to all field of medicine. All the RusOMJ’s articles are published in full on www.romj.org with open access and no limits on word counts. Our mission is to lead the debate on health and to engage, inform, and stimulate doctors, researchers, and other health professionals in ways that will improve outcomes for patients. The RusOMJ team is based mainly in Saratov (Russia), although we also have editors elsewhere in Russian and in other countries.