评价合成漱口水治疗循环障碍性脑病的疗效:观察性临床研究

A. Mitronin, M. Maksimova, D. Ostanina, O. A. Antonova, Yu. A. Mitronin
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引用次数: 0

摘要

背景目前,医学和实践的优先方向是预防牙科疾病,尤其是对有身体病理的患者。循环障碍性脑病患者会发展成一种复杂的神经系统疾病,伴有手、嘴唇和咀嚼肌的运动功能受损,这会导致口腔无法有效清洁食物残渣,并在牙齿表面形成柔软和矿化的牙齿沉积物。因此,这些患者应该使用额外的个人卫生用品。客观的评价使用含合生元复合物的漱口水对循环障碍性脑病患者进行卫生保健的效果。方法。一项观察性临床研究是在A.I.Yevdokimov莫斯科国立医科牙科大学神经病学研究中心2号神经病学单元、Cariology和Endodotics系以及生物化学系的基础上进行的。该研究招募了82名年龄在45至74岁之间的脑血管疾病、循环障碍性脑病、失代偿期患者(根据ICD-10,I68.7)。患者被分为两个研究组:第1组(n=44)——使用含合生元复合物的漱口水的患者;第2组(n=38)——不使用漱口水的患者。通过使用简化的Greene Vermillion口腔卫生指数(OHI-S)、Russell牙周指数(PI)、乳头出血指数(PBI)和口腔液的物理化学参数的指数评分来评估具有合生元复合物的漱口水的功效。使用Stat Plus 7(Analyst Soft股份有限公司,USA)对结果进行统计处理。结果。对比分析证明了含合生元复合物的漱口水的功效。卫生状况改善到(1.50±0.12)分,牙周组织状态改善到(PI=(1.94±1.45)分;PBI=(1.12±0.11)分)。口腔液的氢指数(pH)降至弱碱性值——(7.92±0.22)点;碱性磷酸酶活性下降1.4倍,乳酸脱氢酶下降一半,氨基转移酶下降1.3倍,D-二聚体下降1.2倍。循环障碍性脑病患者的日常口腔卫生护理应包括含合生元复合物的漱口水。
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Evaluating the Efficacy of Synbiotic Mouthwash in Patients with Dyscirculatory Encephalopathy: Observational Clinical Study
Background. At present, the priority direction of medical science and practice is the prevention of dental diseases, especially in patients with somatic pathology. Patients with dyscirculatory encephalopathy develop a complex of neurological disorders, accompanied by impaired motor functions of hands, lips and chewing muscles, which leads to ineffective cleansing of the oral cavity from food residues and formation of soft and mineralized dental deposits on the dental surface. Therefore, these patients should use additional personal hygiene products.Objective. To evaluate the efficacy of hygienic care in patients with dyscirculatory encephalopathy using mouthwash with synbiotic complex.Methods. An observational clinical study was conducted on the basis of Neurology Unit No. 2 of Research Center of Neurology, Department of Cariology and Endodontics and Department of Biological Chemistry, A.I. Yevdokimov Moscow State Medical and Dental University. The study enrolled 82 patients aged from 45 to 74 years with cerebrovascular disease, dyscirculatory encephalopathy, decompensation (I68.7, according to ICD-10). Patients were divided into two study groups: group 1 (n = 44) — patients who used mouthwash with synbiotic complex; group 2 (n = 38) — patients who did not use mouthwash. The efficacy of mouthwash with synbiotic complex was assessed by using an index score of a simplified Greene Vermillion Oral Hygiene Index (OHI-S), Russell Periodontal Index (PI), Papillary Bleeding Index (PBI), and physicochemical parameters of the oral fluid. Statistical processing of the results was carried out using Stat Plus 7 (Analyst Soft Inc., USA).Results. The comparative analysis proved the efficacy of mouthwash with synbiotic complex. The hygienic status improved to (1.50 ± 0.12) points, the state of periodontal tissues — to (PI = (1.94 ± 1.45) points; PBI = (1.12 ± 0.11) points). The hydrogen index (pH) of the oral fluid decreased to weakly alkaline values — (7.92 ± 0.22) points; the activity of alkaline phosphatase decreased by a factor of 1.4, lactate dehydrogenase — by half, aminotransferases — by a factor of 1.3, and D-dimer — by a factor of 1.2.Conclusion. The obtained results demonstrate the efficacy of mouthwash as an additional means for personal hygiene. Mouthwash with synbiotic complex should be included in the daily oral hygiene care for patients with dyscirculatory encephalopathy.
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