GEO数据库中与皮肤光老化相关的mirna表达谱分析

KaHo LUI, Haibo Zhao, Jiaqi Sun, Zeren Shen, Jinghong Xu
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引用次数: 0

摘要

皮肤老化近年来在社会和皮肤护理研究中引起了极大的关注。了解皮肤长期暴露在紫外线下引起的光老化的生物学过程对于预防和治疗皮肤老化至关重要。因此,识别与皮肤光老化相关的基因并阐明其功能是非常重要的。方法利用Gene Expression Omnibus (GEO)数据库数据,进行生物信息学分析,筛选提取与皮肤光老化相关的microRNAs (miRNAs)及其下游靶基因,探讨皮肤光老化可能的生物学机制。结果共鉴定出34个可能与皮肤光老化生物学过程相关的差异表达mirna及其下游靶基因。基因本体富集分析和京都基因与基因组百科全书通路富集分析表明,这些靶基因富集于人乳头瘤病毒感染、细胞外基质(ECM)受体信号转导、雌激素受体、皮肤发育、表皮发育、表皮细胞分化、角质形成细胞分化、ECM结构成分、皮肤表皮结构成分等相关通路。基于GEO数据库衍生的研究结果,我们确定了两个mirna的靶基因miR-4667-5P-KRT79和miR-139-5P-FOS在皮肤光老化中发挥重要作用。这些观察结果可为进一步研究皮肤衰老相关的生物学过程提供理论支持和指导。
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Analysis of the expression profile of miRNAs related to skin photoaging in the GEO database

Background

Skin aging has recently gained significant attention in both society and skin care research. Understanding the biological processes of photoaging caused by long-term skin exposure to ultraviolet radiation is critical for preventing and treating skin aging. Therefore, it is important to identify genes related to skin photoaging and shed light on their functions.

Methods

We used data from the Gene Expression Omnibus (GEO) database and conducted bioinformatics analyses to screen and extract microRNAs (miRNAs) and their downstream target genes related to skin photoaging, and to determine possible biological mechanisms of skin photoaging.

Results

A total of 34 differentially expressed miRNAs and their downstream target genes potentially related to the biological process of skin photoaging were identified. Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that these target genes were enriched in pathways related to human papillomavirus infection, extracellular matrix (ECM)-receptor signaling, estrogen receptor, skin development, epidermal development, epidermal cell differentiation, keratinocyte differentiation, structural components of the ECM, structural components of the skin epidermis, and others.

Conclusion

Based on the GEO database-derived findings, we determined that target genes of two miRNAs, namely miR-4667-5P-KRT79 and miR-139-5P-FOS, play an important role in skin photoaging. These observations could provide theoretical support and guidance for further research on skin aging-related biological processes.

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来源期刊
Chinese Journal of Plastic and Reconstructive Surgery
Chinese Journal of Plastic and Reconstructive Surgery Surgery, Otorhinolaryngology and Facial Plastic Surgery, Pathology and Medical Technology, Transplantation
CiteScore
0.40
自引率
0.00%
发文量
115
审稿时长
55 days
期刊最新文献
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