玻璃体内melphalan治疗持续性视网膜母细胞瘤

Marie Jeazelle H. Redondo-Villanueva, G. V. Mercado
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引用次数: 1

摘要

一例7个月大的男性双侧视网膜母细胞瘤,最初为E组OD和C组OS(国际眼内视网膜母细胞瘤分类)。患者因眼外视网膜母细胞瘤行右眼去核及辅助化疗和放疗。经新辅助化疗联合局灶治疗,左眼主要肿瘤消退,但颞上中外周和下外周有持续的球状玻璃体种子覆盖肿瘤。玻璃体内注射美法兰。注射2个周期后,临床未检出玻璃体种子。第2次玻璃体内注射melphalan 6个月后,左眼未见新的肿瘤和玻璃体种子。未见玻璃体腔内注射美法兰的并发症。这是菲律宾综合医院菲律宾大学眼科肿瘤学/视网膜母细胞瘤科首次记录成功的玻璃体种子玻璃体内melphalan治疗。
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Intravitreal melphalan for persistent retinoblastoma vitreous seeds
A 7-month-old male presented with bilateral retinoblastoma, initially group E OD and group C OS (International Intraocular Retinoblastoma Classification). The patient underwent enucleation with adjuvant chemotherapy and radiotherapy on the right eye for extraocular retinoblastoma. The main tumors on the left eye regressed with combined neoadjuvant chemotherapy with focal therapy, but had persistent sphere vitreous seeds overlying the tumor at the superotemporal mid-periphery and at the inferior periphery. Intravitreal injection of melphalan was performed. Vitreous seeds were clinically undetectable after 2 cycles of injection. Six months from the 2nd intravitreal injection of melphalan, there was no evidence of new tumors nor vitreous seeds in the left eye. No documented complications of intravitreal melphalan injection were experienced. This is the first documented successful treatment of vitreous seeds with intravitreal melphalan at the Ocular Oncology/Retinoblastoma Unit of the University of the Philippines, Philippine General Hospital.
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