{"title":"土壤分离的高原芽孢杆菌/矮孢杆菌复合体对坦桑尼亚姆万扎耐甲氧西林金黄色葡萄球菌的抑菌活性","authors":"Reuben N Abednego, Vitus Silago","doi":"10.4102/ajlm.v12i1.2167","DOIUrl":null,"url":null,"abstract":"<p><p>Antimicrobial resistance in methicillin-resistant <i>Staphylococcus aureus</i> and beta-lactamase-producing Gram-negative bacteria is a global health concern necessitating research and the development of effective antimicrobial agents. This study, conducted in May 2020 in Mwanza, Tanzania, aimed to determine the antibacterial activity of metabolites from soil-isolated <i>Bacillus</i> species against clinical bacterial pathogens. One soil-isolated <i>Bacillus</i> species, identified as <i>Bacillus altitudinis/pumilus</i> complex, showed antibacterial activity against Gram-positive cocci, including a methicillin-resistant <i>S. aureus</i> strain with inducible clindamycin resistance, previously isolated from a patient with osteomyelitis. <i>Bacillus altitudinis/pumilus</i> complex metabolites may be a potential source of antimicrobial agents against multidrug-resistant bacteria.</p><p><strong>What this study adds: </strong>The study supports existing research on the discovery and development of new antimicrobial agents against multi-drug-resistant bacteria. We report the antimicrobial activity of metabolites extracted from soil-isolated <i>Bacillus altitudinis/pumilus</i> complex strains against Gram-positive bacteria, including a methicillin-resistant <i>Staphylococcus aureus</i> strain with inducible clindamycin resistance.</p>","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10716598/pdf/","citationCount":"0","resultStr":"{\"title\":\"Antibacterial activity of soil-isolated <i>Bacillus altitudinis/pumilus</i> complex against methicillin-resistant <i>Staphylococcus aureus</i> from Mwanza, Tanzania.\",\"authors\":\"Reuben N Abednego, Vitus Silago\",\"doi\":\"10.4102/ajlm.v12i1.2167\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Antimicrobial resistance in methicillin-resistant <i>Staphylococcus aureus</i> and beta-lactamase-producing Gram-negative bacteria is a global health concern necessitating research and the development of effective antimicrobial agents. This study, conducted in May 2020 in Mwanza, Tanzania, aimed to determine the antibacterial activity of metabolites from soil-isolated <i>Bacillus</i> species against clinical bacterial pathogens. One soil-isolated <i>Bacillus</i> species, identified as <i>Bacillus altitudinis/pumilus</i> complex, showed antibacterial activity against Gram-positive cocci, including a methicillin-resistant <i>S. aureus</i> strain with inducible clindamycin resistance, previously isolated from a patient with osteomyelitis. <i>Bacillus altitudinis/pumilus</i> complex metabolites may be a potential source of antimicrobial agents against multidrug-resistant bacteria.</p><p><strong>What this study adds: </strong>The study supports existing research on the discovery and development of new antimicrobial agents against multi-drug-resistant bacteria. We report the antimicrobial activity of metabolites extracted from soil-isolated <i>Bacillus altitudinis/pumilus</i> complex strains against Gram-positive bacteria, including a methicillin-resistant <i>Staphylococcus aureus</i> strain with inducible clindamycin resistance.</p>\",\"PeriodicalId\":45412,\"journal\":{\"name\":\"African Journal of Laboratory Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2023-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10716598/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"African Journal of Laboratory Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4102/ajlm.v12i1.2167\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"African Journal of Laboratory Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4102/ajlm.v12i1.2167","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Antibacterial activity of soil-isolated Bacillus altitudinis/pumilus complex against methicillin-resistant Staphylococcus aureus from Mwanza, Tanzania.
Antimicrobial resistance in methicillin-resistant Staphylococcus aureus and beta-lactamase-producing Gram-negative bacteria is a global health concern necessitating research and the development of effective antimicrobial agents. This study, conducted in May 2020 in Mwanza, Tanzania, aimed to determine the antibacterial activity of metabolites from soil-isolated Bacillus species against clinical bacterial pathogens. One soil-isolated Bacillus species, identified as Bacillus altitudinis/pumilus complex, showed antibacterial activity against Gram-positive cocci, including a methicillin-resistant S. aureus strain with inducible clindamycin resistance, previously isolated from a patient with osteomyelitis. Bacillus altitudinis/pumilus complex metabolites may be a potential source of antimicrobial agents against multidrug-resistant bacteria.
What this study adds: The study supports existing research on the discovery and development of new antimicrobial agents against multi-drug-resistant bacteria. We report the antimicrobial activity of metabolites extracted from soil-isolated Bacillus altitudinis/pumilus complex strains against Gram-positive bacteria, including a methicillin-resistant Staphylococcus aureus strain with inducible clindamycin resistance.
期刊介绍：
The African Journal of Laboratory Medicine, the official journal of ASLM, focuses on the role of the laboratory and its professionals in the clinical and public healthcare sectors,and is specifically based on an African frame of reference. Emphasis is on all aspects that promote and contribute to the laboratory medicine practices of Africa. This includes, amongst others: laboratories, biomedical scientists and clinicians, medical community, public health officials and policy makers, laboratory systems and policies (translation of laboratory knowledge, practices and technologies in clinical care), interfaces of laboratory with medical science, laboratory-based epidemiology, laboratory investigations, evidence-based effectiveness in real world (actual) settings.
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