细胞游离DNA;肿瘤学的诊断和预后方法

IF 4.2 Q3 ONCOLOGY Advances in cancer biology - metastasis Pub Date : 2022-10-01 Epub Date: 2022-06-29 DOI:10.1016/j.adcanc.2022.100052

Sjawal Arshad , Muhammad Babar Khawar , Ali Hassan , Ali Afzal , Abdullah Muhammad Sohail , Maryam Mukhtar , Muddasir Hassan Abbasi , Nadeem Sheikh , Arwa Azam , Sara Shahzaman , Syeda Eisha Hamid

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引用次数: 2

摘要

无细胞DNA (cfDNA)是存在于生物液体中的未封装的DNA片段，其平均大小可达200个碱基对。cfDNA的新用途是揭示许多炎症性疾病，特别是癌症的诊断和预后方法的主要候选者。此外，它们作为生物标志物的潜力是由于它们在体内无处不在，非侵入性，并有助于不同的尸检方法。本文将重点讨论cfDNA作为非侵入性生物标志物在肿瘤学中的诊断和预后潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cell free DNA; diagnostic and prognostic approaches to oncology

Cell-free DNA (cfDNA) are un-encapsulated DNA fragments present in biological fluids ranging in an average size of up to 200 base pairs. The novel use of cfDNA is a prime candidate in the diagnostic and prognostic approach to unveiling many inflammatory diseases, especially cancer. Moreover, their potential as biomarkers is due to their ubiquitous presence in the body, non-invasive nature, and aiding in a different autopsy method. This review will focus on the diagnostic and prognostic potential of cfDNA as non-invasive biomarkers in oncology.

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