Immune-Metabolic Stress in Purulent-Inflammatory Diseases of the Skin and Soft Tissues

It is known that metabolic processes include free radical oxidations (ROS), which provide cells with energy to prepare plastic material, participate in the metabolism of carbohydrates, lipids, proteins, nucleic acids. ROS leads to the formation of primary (diene conjugate [DC], ketodienes [KD]) and secondary (malonic dialdehyde [MDA], bityrozine crosslinks [BC], Schiff ’s bases [SHB]) and other products that have a positive or negative effect on the biomembrane cells. For the leveling of ROS processes in the body, an endogenous antioxidant defense system (AOD) is developed, which consists of enzymatic and non-enzymatic links. The first group includes superoxide dismutase (SOD), catalase (C), peroxidase (P), glutathion peroxidase (GP), glutathione reductase (GR); to the second, glutathione (GL), alpha-tocopherol (vitamin E, VE), plasma antioxidant activity (AOA), total thiols, non-protein thiols, protein thiols (TT, NPT, PT), etc. [1,2]. It has been established that ROS products mainly implement a suppressive and AOD a modulating effect on the immune reactivity of patients [3]. At the same time, the direct link between immune-metabolic parameters, recognized by all authors is practically not documented [4-7].